Benzoxazomycin
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| Category | Antibiotics |
| Catalog number | BBF-03123 |
| CAS | |
| Molecular Weight | 636.77 |
| Molecular Formula | C36H48N2O8 |
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Description
Benzoxazomycin is an ansa antibiotic produced by Str. sp. MJ672-m3. It can inhibit the growth of tumor cells such as NCI-H522, NCI-H469, OVCAR-5, St-4 and BSY-1.
Specification
| IUPAC Name | [(4E,10E,12Z)-6,22-dihydroxy-16-methoxy-5,7-dimethyl-18-oxo-25-oxa-19-azatetracyclo[12.9.2.015,19.020,24]pentacosa-1(24),4,10,12,20,22-hexaen-8-yl] 2-(cyclohexanecarbonylamino)propanoate |
| Canonical SMILES | CC1C(CC=CC=CC2C3C(CC(=O)N3C4=CC(=CC(=C4O2)CCC=C(C1O)C)O)OC)OC(=O)C(C)NC(=O)C5CCCCC5 |
| InChI | InChI=1S/C36H48N2O8/c1-21-12-11-15-25-18-26(39)19-27-34(25)45-29(32-30(44-4)20-31(40)38(27)32)17-10-6-9-16-28(22(2)33(21)41)46-36(43)23(3)37-35(42)24-13-7-5-8-14-24/h6,9-10,12,17-19,22-24,28-30,32-33,39,41H,5,7-8,11,13-16,20H2,1-4H3,(H,37,42)/b9-6+,17-10-,21-12+ |
| InChI Key | QOCVCLXEQORBEY-APUNVNHRSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 847.0±65.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin
N Hosokawa, H Naganawa, M Hamada, H Iinuma, T Takeuchi, K S Tsuchiya, M Hori J Antibiot (Tokyo). 2000 Sep;53(9):886-94. doi: 10.7164/antibiotics.53.886.
New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
