BM-2419-1
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03248 |
| CAS | |
| Molecular Weight | 354.27 |
| Molecular Formula | C18H10O8 |
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Description
BM2419-1 is a human topoisomerase I inhibitor produced by Paecilomyces sp. BM2419. It can selectively inhibit human topoisomerase with an IC50 of 0.3 ng/mL.
Specification
| IUPAC Name | 1,3,6,8,10,11-hexahydroxytetracene-5,12-dione |
| Canonical SMILES | C1=C(C=C(C2=C1C(=C3C(=C2O)C(=O)C4=C(C3=O)C=C(C=C4O)O)O)O)O |
| InChI | InChI=1S/C18H10O8/c19-5-1-7-11(9(21)3-5)17(25)14-13(15(7)23)16(24)8-2-6(20)4-10(22)12(8)18(14)26/h1-4,19-23,25H |
| InChI Key | PHYUQMBGSCMYTB-UHFFFAOYSA-N |
Properties
| Appearance | Purple Powder |
| Boiling Point | 805.2±60.0°C at 760 mmHg |
| Density | 1.9±0.1 g/cm3 |
Reference Reading
1. Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin
D Ishiyama, K Futamata, M Futamata, O Kasuya, S Kamo, F Yamashita, S Kanazawa J Antibiot (Tokyo). 1998 Dec;51(12):1069-74. doi: 10.7164/antibiotics.51.1069.
Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
