BM-2419-2
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03249 |
| CAS | |
| Molecular Weight | 352.29 |
| Molecular Formula | C19H12O7 |
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Description
BM2419-2 is a human topoisomerase I inhibitor produced by Paecilomyces sp. BM2419. It can selectively inhibit human topoisomerase with an IC50 of 0.6 ng/mL.
Specification
| IUPAC Name | 1,3,8,10,11-pentahydroxy-6-methyltetracene-5,12-dione |
| Canonical SMILES | CC1=C2C=C(C=C(C2=C(C3=C1C(=O)C4=C(C3=O)C(=CC(=C4)O)O)O)O)O |
| InChI | InChI=1S/C19H12O7/c1-6-9-2-7(20)4-11(22)14(9)18(25)16-13(6)17(24)10-3-8(21)5-12(23)15(10)19(16)26/h2-5,20-23,25H,1H3 |
| InChI Key | QPTIGEXZMBTRSE-UHFFFAOYSA-N |
Properties
| Appearance | Orange Powder |
| Boiling Point | 690.3±55.0°C at 760 mmHg |
| Density | 1.7±0.1 g/cm3 |
Reference Reading
1. Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin
D Ishiyama, K Futamata, M Futamata, O Kasuya, S Kamo, F Yamashita, S Kanazawa J Antibiot (Tokyo). 1998 Dec;51(12):1069-74. doi: 10.7164/antibiotics.51.1069.
Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
