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BM-2419-2

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Category Enzyme inhibitors
Catalog number BBF-03249
CAS
Molecular Weight 352.29
Molecular Formula C19H12O7

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

BM2419-2 is a human topoisomerase I inhibitor produced by Paecilomyces sp. BM2419. It can selectively inhibit human topoisomerase with an IC50 of 0.6 ng/mL.

  • Specification
  • Properties
  • Reference Reading
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IUPAC Name 1,3,8,10,11-pentahydroxy-6-methyltetracene-5,12-dione
Canonical SMILES CC1=C2C=C(C=C(C2=C(C3=C1C(=O)C4=C(C3=O)C(=CC(=C4)O)O)O)O)O
InChI InChI=1S/C19H12O7/c1-6-9-2-7(20)4-11(22)14(9)18(25)16-13(6)17(24)10-3-8(21)5-12(23)15(10)19(16)26/h2-5,20-23,25H,1H3
InChI Key QPTIGEXZMBTRSE-UHFFFAOYSA-N
Appearance Orange Powder
Boiling Point 690.3±55.0°C at 760 mmHg
Density 1.7±0.1 g/cm3
1. Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin
D Ishiyama, K Futamata, M Futamata, O Kasuya, S Kamo, F Yamashita, S Kanazawa J Antibiot (Tokyo). 1998 Dec;51(12):1069-74. doi: 10.7164/antibiotics.51.1069.
Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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