Boholmycin
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| Category | Antibiotics |
| Catalog number | BBF-00162 |
| CAS | 117192-99-1 |
| Molecular Weight | 764.68 |
| Molecular Formula | C27H48N4O21 |
| Purity | >98% |
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Description
Boholmycin is an amino glycoside antibiotic produced by Streptomyces hygrosspicus H617-25. Its antibacterial activity is weak, but its antibacterial spectrum is broad, and it also has an effect on aminoglycosine-resistant bacteria.
Specification
| Synonyms | D-scyllo-Inositol, O-3-amino-3-deoxy-alpha-D-mannopyranosyl-(1-3)-O-(O-heptopyranosyl-(1-4)-2-deoxy-2-(methylamino)-alpha-D-xylopyranosyl-(1-1))-, 4,6-dicarbamate |
| Storage | Store at -20°C |
| IUPAC Name | [4-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-carbamoyloxy-2-[5-[6-(1,2-dihydroxyethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4-hydroxy-3-(methylamino)oxan-2-yl]oxy-3,6-dihydroxycyclohexyl] carbamate |
| Canonical SMILES | CNC1C(C(COC1OC2C(C(C(C(C2OC(=O)N)O)OC(=O)N)OC3C(C(C(C(O3)CO)O)N)O)O)OC4C(C(C(C(O4)C(CO)O)O)O)O)O |
| InChI | InChI=1S/C27H48N4O21/c1-31-9-11(36)7(47-25-15(40)13(38)14(39)18(48-25)5(34)2-32)4-45-23(9)49-19-16(41)20(22(52-27(30)44)17(42)21(19)51-26(29)43)50-24-12(37)8(28)10(35)6(3-33)46-24/h5-25,31-42H,2-4,28H2,1H3,(H2,29,43)(H2,30,44) |
| InChI Key | JPGBWUBDJIISRF-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | bacteria |
| Boiling Point | 1171.4°C at 760 mmHg |
| Melting Point | 214-219°C(dec.) |
| Density | 1.75 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1. Boholmycin, a new aminoglycoside antibiotic. I. Production, isolation and properties
K Saitoh, M Tsunakawa, K Tomita, T Miyaki, M Konishi, H Kawaguchi J Antibiot (Tokyo). 1988 Jul;41(7):855-61. doi: 10.7164/antibiotics.41.855.
A novel aminoglycoside antibiotic, boholmycin, was produced by Streptomyces hygroscopicus H617-25 isolated from a soil sample collected in Bohol Island, the Philippines. It has a pseudotetrasaccharide structure composed of a heptose, two aminosugars and dicarbamoyl-scyllo-inositol. Intrinsic antibacterial activity of boholmycin is weak but it exhibits broad spectrum activity against Gram-positive and Gram-negative bacteria including aminoglycoside-resistant strains. Boholmycin is non-toxic in mice at 1,000 mg/kg intravenously.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
