Brilacidin
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Category | Antibiotics |
Catalog number | BBF-04174 |
CAS | 1224095-98-0 |
Molecular Weight | 936.90 |
Molecular Formula | C40H50F6N14O6 |
Purity | 98% |
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Description
An investigational antibiotic effective against Gram-positive and Gram-negative bacteria, which is a non-peptide small molecule modeled after host defense peptides (HDPs). It is currently under clinical trials for the treatment of head and neck neoplasms as well as mucositis.
Specification
Synonyms | PMX30063; PMX-30063; PMX 30063 |
Storage | Store at -20°C |
IUPAC Name | 4-N,6-N-bis[3-[5-(diaminomethylideneamino)pentanoylamino]-2-[(3R)-pyrrolidin-3-yl]oxy-5-(trifluoromethyl)phenyl]pyrimidine-4,6-dicarboxamide |
Canonical SMILES | C1CNCC1OC2=C(C=C(C=C2NC(=O)C3=CC(=NC=N3)C(=O)NC4=CC(=CC(=C4OC5CCNC5)NC(=O)CCCCN=C(N)N)C(F)(F)F)C(F)(F)F)NC(=O)CCCCN=C(N)N |
InChI | InChI=1S/C40H50F6N14O6/c41-39(42,43)21-13-25(57-31(61)5-1-3-9-53-37(47)48)33(65-23-7-11-51-18-23)27(15-21)59-35(63)29-17-30(56-20-55-29)36(64)60-28-16-22(40(44,45)46)14-26(34(28)66-24-8-12-52-19-24)58-32(62)6-2-4-10-54-38(49)50/h13-17,20,23-24,51-52H,1-12,18-19H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H4,47,48,53)(H4,49,50,54)/t23-,24-/m1/s1 |
InChI Key | QPDYBCZNGUJZDK-DNQXCXABSA-N |
Properties
Appearance | Solid Powder |
Application | Anti-Infective Agents |
Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor) |
Density | 1.6±0.1 g/cm3 |
Solubility | Soluble in DMSO |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2