Bu-2841-10
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| Category | Bioactive by-products |
| Catalog number | BBF-02755 |
| CAS | |
| Molecular Weight | 1477.61 |
| Molecular Formula | C68H100N16O21 |
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Description
Bu-2841-10 is a cyclic ester peptide originally isolated from K-341-B7. It has activity against gram-positive bacteria.
Specification
| IUPAC Name | 2-[6,30-bis(2-aminoethyl)-21-(2-amino-2-oxoethyl)-3-benzyl-9-butan-2-yl-18-(carboxymethyl)-33-[[3-hydroxy-2-[(3-hydroxy-8-methyldecanoyl)amino]propanoyl]amino]-12-(1H-indol-3-ylmethyl)-34-methyl-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-1-oxa-4,7,10,13,16,19,22,25,28,31-decazacyclotetratriacont-27-yl]acetic acid |
| Canonical SMILES | CCC(C)CCCCC(CC(=O)NC(CO)C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC1=O)CCN)CC(=O)O)CC(=O)N)CC(=O)O)CC2=CNC3=CC=CC=C32)C(C)CC)CCN)CC4=CC=CC=C4)C)O |
| InChI | InChI=1S/C68H100N16O21/c1-6-35(3)15-11-12-18-40(86)27-52(88)77-50(34-85)65(101)84-58-37(5)105-68(104)49(25-38-16-9-8-10-17-38)82-62(98)44(22-24-70)78-66(102)57(36(4)7-2)83-64(100)45(26-39-31-72-42-20-14-13-19-41(39)42)75-53(89)32-73-60(96)48(30-56(93)94)81-63(99)46(28-51(71)87)76-54(90)33-74-59(95)47(29-55(91)92)80-61(97)43(21-23-69)79-67(58)103/h8-10,13-14,16-17,19-20,31,35-37,40,43-50,57-58,72,85-86H,6-7,11-12,15,18,21-30,32-34,69-70H2,1-5H3,(H2,71,87)(H,73,96)(H,74,95)(H,75,89)(H,76,90)(H,77,88)(H,78,102)(H,79,103)(H,80,97)(H,81,99)(H,82,98)(H,83,100)(H,84,101)(H,91,92)(H,93,94) |
| InChI Key | FTXBOLNDVPQAFJ-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 1907.2±65.0°C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. Structure of new cyclic depsipeptides, Bu-2841-08 and -10
T Fukai, J Kuroda, M Konishi, T Nomura, N Naruse, R Isobe J Antibiot (Tokyo). 1995 Oct;48(10):1115-23. doi: 10.7164/antibiotics.48.1115.
The structures of new antibiotics, Bu-2841-08 and -10, have been determined. They are cyclic depsipeptides and the sequence of amino acid residues was established by mass spectral analysis of the hydrolyzed linear peptide and NMR spectral analysis of the parent cyclic peptides.
2. Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
T Fukai, J Kuroda, T Nomura J Am Soc Mass Spectrom. 2000 May;11(5):458-63. doi: 10.1016/S1044-0305(00)00109-4.
We report the application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the accurate measurement of mass of low molecular weight compounds (smaller than 1500 Da), a linear peptide, two types of cyclic depsipeptides, a polyhydroxy-macrocyclic lactone, and two prenylated flavonoids, with delayed extraction in the reflector mode. The performance of the MALDI-TOF instrument was less than those of fast atom bombardment and Fourier-transform ion cyclotron resonance mass spectrometry instruments and insufficient to give acceptable accuracy for literature reporting. Nevertheless, when combined with NMR spectrometry and/or amino acid analysis to give information on the numbers of carbon atoms and index of hydrogen deficiency, MALDI was useful for determination of the elemental composition of the low molecular weight compounds available in small quantities.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
