C-19393 E5
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02759 |
| CAS | 83310-72-9 |
| Molecular Weight | 328.34 |
| Molecular Formula | C13H16N2O6S |
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Description
It is produced by the strain of Streptomyces griseus subsp. cryophilus C-19393. C-19393 E5 has anti-gram-positive and anti-gram-negative bacteria activity and strong β-lactamase inhibition.
Specification
| Synonyms | Antibiotic C 19393E5; C-19393 E(5) |
| IUPAC Name | (5R,6R)-3-[(R)-[(E)-2-acetamidoethenyl]sulfinyl]-6-[(1S)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Canonical SMILES | CC(C1C2CC(=C(N2C1=O)C(=O)O)S(=O)C=CNC(=O)C)O |
| InChI | InChI=1S/C13H16N2O6S/c1-6(16)10-8-5-9(22(21)4-3-14-7(2)17)11(13(19)20)15(8)12(10)18/h3-4,6,8,10,16H,5H2,1-2H3,(H,14,17)(H,19,20)/b4-3+/t6-,8+,10-,22+/m0/s1 |
| InChI Key | OLJZNOCSKZHZQJ-QGKPYDHGSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 706.5±60.0°C at 760 mmHg |
| Density | 1.6±0.1 g/cm3 |
Reference Reading
1. C-19393 E5, a new carbapenem antibiotic. Fermentation, isolation and structure
S Harada, Y Nozaki, S Shinagawa, K Kitano J Antibiot (Tokyo). 1982 Aug;35(8):957-62. doi: 10.7164/antibiotics.35.957.
A new carbapenem antibiotic, C-19393 E5, was isolated from the culture filtrate of Streptomyces griseus subsp. cryophilus C-19393 as a minor component. The chemical structure of the antibiotic was determined by comparing its spectral data with those of the known 5,6-cis carbapenem antibiotics and confirmed by partial synthesis from epithienamycin B as shown in Fig. 1. The antibiotic has a broad antimicrobial spectrum and shows strong inhibitory activity against beta-lactamases.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
