Caldariomycin

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Caldariomycin
Category Antibiotics
Catalog number BBF-00203
CAS 465-61-2
Molecular Weight 171.02
Molecular Formula C5H8Cl2O2

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Description

Caldariomycin is an alicyclic antibiotic produced by Caldariomyces fumago. Anti-Gram-positive bacteria.

Specification

IUPAC Name (1S,3S)-2,2-dichlorocyclopentane-1,3-diol
Canonical SMILES C1CC(C(C1O)(Cl)Cl)O
InChI InChI=1S/C5H8Cl2O2/c6-5(7)3(8)1-2-4(5)9/h3-4,8-9H,1-2H2/t3-,4-/m0/s1
InChI Key CXQAMTQEGSVLDJ-IMJSIDKUSA-N

Properties

Appearance Colorless needle Crystal
Antibiotic Activity Spectrum Gram-positive bacteria
Solubility Soluble in Methanol, Water

Reference Reading

1. Isolation of the bromo analogue of caldariomycin from Caldariomyces fumago
E L Patterson, W W Andres, L A Mitscher Appl Microbiol. 1967 May;15(3):528-30. doi: 10.1128/am.15.3.528-530.1967.
When bromide ion was substituted for chloride in the growth medium of Caldariomyces fumago, a new substance was produced. It was isolated by solvent extraction and purified by alumina chromatography. Examination of the physicochemical properties of the substance led to its identification as the bromo analogue of the normal metabolite, caldariomycin. Thus, biological substitution of bromine for chlorine has been demonstrated in the metabolic formation of a purely aliphatic secondary mold metabolite.

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