Castanospermine
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category | Enzyme inhibitors |
Catalog number | BBF-03754 |
CAS | 79831-76-8 |
Molecular Weight | 189.21 |
Molecular Formula | C8H15NO4 |
Purity | >98% |
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Capabilities & Facilities
Fermentation Lab
4 R&D and scale-up labs
2 Preparative purification labs
Fermentation Plant
Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
Castanospermine is an inhibitor of all forms of α- and β-glucosidases, especially glucosidase l. It inhibits lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively. It also inhibits lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively. It inhibits HIV syncytium formation and replication. It catalyzes the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. It is effective both in vitro and in vivo. It blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions, including angiogenesis. It also interferes with viral replication and infection. It is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro.
- Specification
- Properties
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Synonyms | (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; 1,6,7,8-Indolizinetetrol, octahydro-, [1S-(1α,6β,7α,8β,8aβ)]-; (+)-Castanospermine; NSC 614552; (1S,6S,7R,8R,8aR)-Octahydroindolizine-1,6,7,8-tetraol; (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine; 6,7-Diepicastanospermine |
Shelf Life | 2 month in rt, long time |
Storage | Store at 2-8 °C |
IUPAC Name | (1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,6,7,8-tetrol |
Canonical SMILES | C1CN2CC(C(C(C2C1O)O)O)O |
InChI | InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5-,6+,7+,8+/m0/s1 |
InChI Key | JDVVGAQPNNXQDW-TVNFTVLESA-N |
Source | Castanospermum australe (plant extract) |
Appearance | White to Yellow Powder |
Application | Castanospermine inhibits HIV syncytium formation and replication. It catalyzes the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. It blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions, including angiogenesis. It also interferes with viral replication and infection. |
Boiling Point | 421.9±45.0 °C at 760 mmHg |
Melting Point | 204-206 °C (dec.) |
Density | 1.53±0.1 g/cm3 |
Solubility | Soluble in DMSO, Water |
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
