Cedarmycin B
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-00500 |
| CAS | 363624-70-8 |
| Molecular Weight | 226.27 |
| Molecular Formula | C12H18O4 |
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Description
It is produced by the strain of Streptomyces sp. TP-A0456. It has activities against candida, Cryptococcus neoforme and aspergillus fumigatus. MIC is 12.5-50 ㎍/mL. The anti-bacterial activity is weak.
Specification
| Synonyms | (4-Methylene-5-oxo-3-2,3-dihydrofuryl)methyl hexanoate; CTK6D6764; (4-methylene-5-oxo-tetrahydrofuran-3-yl)methyl hexanoate |
| IUPAC Name | (4-methylidene-5-oxooxolan-3-yl)methyl hexanoate |
| Canonical SMILES | CCCCCC(=O)OCC1COC(=O)C1=C |
| InChI | InChI=1S/C12H18O4/c1-3-4-5-6-11(13)15-7-10-8-16-12(14)9(10)2/h10H,2-8H2,1H3 |
| InChI Key | ZUGWRISHBCSTOJ-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Oily Matter |
| Antibiotic Activity Spectrum | fungi |
| Solubility | Soluble in Chloroform, Methanol |
Reference Reading
1. Cedarmycins A and B, new antimicrobial antibiotics from Streptomyces sp. TP-A0456
T Sasaki, Y Igarashi, N Saito, T Furumai J Antibiot (Tokyo). 2001 Jul;54(7):567-72. doi: 10.7164/antibiotics.54.567.
Two novel butyrolactone antibiotics, cedarmycins A and B, were isolated from the cultured broth of the actinomycete Streptomyces sp. TP-A0456. The new compounds were purified by HP-20 resin, silica gel, ODS column chromatographies and preparative HPLC, consecutively. The structure of cedarmycin was determined by spectroscopic methods as an alpha,beta-unsaturated butyrolactone with a fatty acid side chain. These compounds showed antibiotic activity against Gram-positive and -negative bacteria and yeasts. Among the tested organisms, cedarmycins potently inhibited the growth of Candida glabrata IFO 0622 with the MIC of 0.4 microg/ml, comparable to that of amphotericin B.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
