Ceftazidime pentahydrate
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| Category | Antibiotics |
| Catalog number | BBF-04535 |
| CAS | 78439-06-2 |
| Molecular Weight | 636.65 |
| Molecular Formula | C22H22N6O7S2.5H2O |
| Purity | 95% |
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Description
Ceftazidime is a third generation cephalosporin antibiotic useful for the treatment of bacterial infections. It can be used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, pseudomonas aeruginosa infection and vibrio infection.
Specification
| Related CAS | 72558-82-8 (free base) |
| Synonyms | 1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium Inner Salt Pentahydrate; Biotum; Ceftacidin; Fortam; Fortaz; Fortum; GR 20263; Modacin; Tazicef; Tazidime |
| Storage | Store at 2-8°C |
| IUPAC Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate |
| Canonical SMILES | CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-].O.O.O.O.O |
| InChI | InChI=1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1.../s1 |
| InChI Key | NMVPEQXCMGEDNH-TZVUEUGBSA-N |
| Source | Synthetic |
Properties
| Appearance | White or Off-white Powder |
| Application | Third Generation Cephalosporins |
| Antibiotic Activity Spectrum | Bacteria |
| Melting Point | >191°C (dec.) |
| Solubility | Slightly soluble in DMSO, Methanol |
Reference Reading
1.Antibiotic susceptibility pattern and identification of extended spectrum β-lactamases (ESBLs) in clinical isolates of Klebsiella pneumoniae from Shiraz, Iran.
Mansury D1, Motamedifar M2, Sarvari J3, Shirazi B4, Khaledi A5. Iran J Microbiol. 2016 Feb;8(1):55-61.
BACKGROUND AND OBJECTIVES: Klebsiella pneumoniae, one of the important causes of nosocomial infections, is the most common extended spectrum β-lactamases (ESBLs) producing organism. ESBLs are defined as the enzymes capable of hydrolyzing oxyimino-cephalosporins, monobactams and carbapenems. The aims of this study were to identify ESBL-producing K. pneumoniae isolates and detect their antibiotic susceptibility pattern.
2.Prevalence and susceptibility patterns of bacteria causing respiratory tract infections in North Waziristan, Pakistan.
Shah SN1, Ullah B1, Basit A1, Begum A1, Tabassum A1, Zafar S2, Saleha S3. Pak J Pharm Sci. 2016 Mar;29(2 Suppl):701-6.
Respiratory tract infections (RTIs) are the most common infectious diseases in humans and are the major cause of mortality and morbidity in Pakistan. These infections are the leading causes of consultations in primary care in Pakistan. Therefore, this study was aimed at determining bacterial pathogens of respiratory tract infections and the susceptibility patterns of bacterial isolates to antibiotics. The study was conducted between February, 2013 and March, 2014 in North Waziristan region of Pakistan. Sputum specimens were collected aseptically from 227 patients and cultured on the appropriate bacteriological media. Bacterial isolates were identified by biochemical tests and their antibiotics susceptibility patterns were determined by standard methods. Out of 227, various species of bacteria were isolated from 152 (75%) specimens. The prevalence of bacteria species isolated were as follows Pseudomonas aeruginosa (42.8%), Streptococcus pneumoniae (26.
3.[Uropathogen pattern and antimicrobial susceptibility in positive urinary cultures isolates from paediatric patients].
Moya-Dionisio V1, Díaz-Zabala M, Ibáñez-Fernández A, Suárez-Leiva P, Martínez-Suárez V, Ordóñez-Álvarez FA, Santos-Rodríguez F. Rev Esp Quimioter. 2016 Apr 19. pii: moya19apr2016. [Epub ahead of print]
OBJECTIVE: Knowledge of urophatogens and antibiotic susceptibility should be used to assist with empirical urinary tract infection treatment.
4.Phenotypic Tests for the Detection of β-Lactamase-Producing Enterobacteriaceae Isolated from Different Environments.
de Oliveira DV1, Van Der Sand ST2. Curr Microbiol. 2016 Apr 12. [Epub ahead of print]
Some bacteria from the Enterobacteriaceae family are showing a significant capability to disseminate β-lactams resistance mechanisms among them, and these same mechanisms can be carried out from the hospital environment to superficial water. The aim of this study was to evaluate different phenotypic methods for the detection β-lactamases production by enterobacteria isolated from the anthropogenic environment: hospital wastewater and from a stream that cross the city of Porto Alegre. The applied tests were the modified Hodge test (MHT) and phenotypic tests with the following inhibitors: carbapenemase-phenylboronic acid (APB), metallo-β-lactamase-EDTA, AmpC β-lactamase-cloxacillin, and the confirmatory test for extended-spectrum β-lactamase (ESBL)-clavulanic acid. For this evaluation, 131 isolates were initially subjected to antibiogram using the following antimicrobials: cefotaxime (30 µg), cefpodoxime (10 μg), ceftazidime (30 µg), ertapenem (10 μg), meropenem (10 μg), and aztreonam (30 μg).
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
