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Cephaloridine

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Cephaloridine
Category Antibiotics
Catalog number BBF-00757
CAS 50-59-9
Molecular Weight 415.48
Molecular Formula C19H17N3O4S2
Purity 95%

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Semisynthetic first generation cephalosporin for injection. Cephaloridine had the same antibacterial spectrum as Cephalothin, but had stronger antibacterial effect than Cephalothin. Oral malabsorption, The drug is excreted 75%-80% in the urine by injection for 24h. The half-life of normal plasma elimination was 1.5h, and the binding rate of plasma protein was 22%.

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Related CAS 102039-86-1 (hydrate)
Synonyms cefaloridine; Cefaloridin; Cephaloridin; Cephaloridinum; Cefalorizin; Cephalomycine; N-(7-((2-Thienyl)acetamido)ceph-3-em-3-ylmethyl)pyridinium-4-carboxylate; 7-((2-Thienyl)acetamido)-3-(1-pyridylmethyl)cephalosporanic acid
Storage 2-8 °C
IUPAC Name (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Canonical SMILES C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4
InChI InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1
InChI Key CZTQZXZIADLWOZ-CRAIPNDOSA-N
Appearance White Crystal Powder
Melting Point 184 °C
Density 1.323 g/cm3 (Predicted)
Solubility Soluble in Water
1.Prevalence of bla(PenA) and bla(OXA) in Burkholderia pseudomallei Isolated from Patients at Sappasitthiprasong Hospital and Their Susceptibility to Ceftazidime and Carbapenems.
Panya M, Thirat S, Wanram S, Panomket P, Nilsakul J. J Med Assoc Thai. 2016 Jan;99 Suppl 1:S12-6.
BACKGROUND: Burkholderia pseudomallei is a causative agent of melioidosis. Ceftazidime is the preferred drug of choice for treatment. However, the motility rate is high in endemic areas.
2.Metastatic endophthalmitis combined with subretinal abscess in a patient with diabetes mellitus--a case report.
Tsai TH1, Peng KL2. BMC Ophthalmol. 2015 Aug 14;15:105. doi: 10.1186/s12886-015-0079-y.
BACKGROUND: Endogenous endophthalmitis, extra-hepatic metastasis from liver abscess with diabetes mellitus, could lead to a devastating outcome without a prompt and appropriate management. We report a case of metastatic endophthalmitis combined with subretinal abscess with successful visual outcome after treatment.
3.Antibiotic susceptibility of sulfamethoxazole-trimethoprim resistant Stenotrophomonas maltophilia strains isolated at a tertiary care centre in Hungary.
Juhász E1, Pongrácz J1, Iván M1, Kristóf K1. Acta Microbiol Immunol Hung. 2015 Sep;62(3):295-305. doi: 10.1556/030.62.2015.3.7.
Sulfamethoxazole-trimethoprim (SXT) is the drug-of-choice in Stenotrophomonas maltophilia caused infections. There has been an increase in resistance to SXT of S. maltophilia over recent years. In this study 30 S. maltophilia clinical isolates resistant to SXT were investigated. Antibiotic susceptibilities for ciprofloxacin, moxifloxacin, levofloxacin, doxycycline, tigecycline, ceftazidime, colistin and chloramphenicol were determined by broth microdilution method. None of the strains were susceptible to ciprofloxacin, tigecycline, ceftazidime or colistin. Only 37% of the isolates were susceptible to levofloxacin or moxifloxacin. Two isolates resistant to all tested antibiotic agents and two others susceptible only to doxycycline were further investigated: susceptibility for combinations of antibiotics was analyzed by checkerboard technique. According to the fractional inhibitory concentration indices calculated, moxifloxacin plus ceftazidime combination was found to be synergistic in each case.
4.A β-lactamase inhibitor revival provides new hope for old antibiotics.
Garber K. Nat Rev Drug Discov. 2015 Jul;14(7):445-7. doi: 10.1038/nrd4666.

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