Cephalothin sodium
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| Category | Antibiotics |
| Catalog number | BBF-04538 |
| CAS | 58-71-9 |
| Molecular Weight | 418.41 |
| Molecular Formula | C16H15N2NaO6S2 |
| Purity | ≥98% |
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Description
Cephalothin sodium is a semisynthetic first generation cephalosporin antibiotic having a broad spectrum of antibacterial activity that is administered parenterally used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or join. It is active against gram-positive and gram-negative bacteria.
Specification
| Related CAS | 153-61-7 (free acid) |
| Synonyms | 7-(Thiophene-2-acetamido)cephalosporanic acid sodium; (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; 7-[2-(2-Thienyl)acetylamido]cephalosporanic Acid Sodium Salt; CT Sodium; Sodium Cefalotin; Sodium Cephalotin; Keflin; Seffin; Toricelocin |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage | Store at -20°C under inert atmosphere |
| IUPAC Name | sodium;(6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Canonical SMILES | CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)[O-].[Na+] |
| InChI | InChI=1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1 |
| InChI Key | VUFGUVLLDPOSBC-XRZFDKQNSA-M |
| Source | Semi-synthetic |
Properties
| Appearance | White to Off-white Solid |
| Application | Anti-Bacterial Agents |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 757.2°C at 760 mmHg |
| Melting Point | >163°C |
| Solubility | Slightly soluble in Chloroform, DMSO (Heated), Methanol (Heated), Water |
Reference Reading
1.In vitro and in vivo laboratory evaluation of cephalothin, a new broad spectrum antibiotic.
BONIECE WS, WICK WE, HOLMES DH, REDMAN CE. J Bacteriol. 1962 Dec;84:1292-6.
Boniece, W. S. (Lilly Research Laboratories, Indianapolis, Indiana), W. E. Wick, D. H. Holmes, and C. E. Redman. In vitro and in vivo laboratory evaluation of cephalothin, a new broad-spectrum antibiotic. J. Bacteriol. 84:1292-1296. 1962.-Cephalothin, a new cephalosporin antibiotic, is the sodium salt of 7-(thiophene-2-acetamido) cephalosporanic acid. The activity of this antibiotic against a variety of gram-positive and gram-negative bacteria is described, as determined by the tube-dilution and disc-plate methods. Correlations of the results of the therapy of experimental infections in mice with in vitro sensitivity to cephalothin are presented. The data from the gram-negative bacterial infection tests suggest the following relationship on a within strain basis: ed(50) = C(i)ld(50) (bi), where the subscript i stands for the various strains.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
