Cervicarcin
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| Category | Antibiotics |
| Catalog number | BBF-00521 |
| CAS | 18700-78-2 |
| Molecular Weight | 392.36 |
| Molecular Formula | C19H20O9 |
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Description
It is produced by the strain of Streptomyces ogaensis 1390. It had a strong inhibitory effect on sarcoma 180 and sarcoma NF, but had a weak effect on sarcoma 37, Ehrman's ascites cancer and Friend leukemia.
Specification
| Synonyms | NSC65380; NSC 65380; NSC-65380; 1,3,4,5,10-Pentahydroxy-2-methyl-3-[(3-methyloxiran-2-yl)carbonyl]-1,2,3,4-tetrahydro-4a,9a-epoxyanthracen-9(10H)-one; 4a,9a-Epoxy-3-(2,3-epoxybutyryl)-1,2,3,4,4a,9a-hexahydro-1,3,4,5,10-pentahydroxy-2-methyl-anthrone |
| IUPAC Name | 7,9,11,12,14-pentahydroxy-13-methyl-12-(3-methyloxirane-2-carbonyl)-15-oxatetracyclo[8.4.1.01,10.03,8]pentadeca-3(8),4,6-trien-2-one |
| Canonical SMILES | CC1C(C23C(=O)C4=C(C(C2(O3)C(C1(C(=O)C5C(O5)C)O)O)O)C(=CC=C4)O)O |
| InChI | InChI=1S/C19H20O9/c1-6-12(21)18-13(22)8-4-3-5-9(20)10(8)14(23)19(18,28-18)16(25)17(6,26)15(24)11-7(2)27-11/h3-7,11-12,14,16,20-21,23,25-26H,1-2H3 |
| InChI Key | ZGZVMKCZHDIFQA-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Acicular Crystal |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 686.0 °C at 760 mmHg |
| Melting Point | 203-205 °C (dec.) |
| Density | 1.74 g/cm3 |
| Solubility | Highly soluble in Alkali Water, Low Alcohol, Acetone, Pyridine, Acetic acid; Soluble in Ethyl Acetate, Ether, Chloroform; Slightly soluble in Benzene, Water; Insoluble in Petroleum Ether |
Reference Reading
1. Arginase is involved in cervical lesions progression and severity
Moufida Souid, Randa Ghedira, Sameh Souissi, Nadia Bouzgarrou, Sallouha Gabbouj, Salwa Shini-Hadhri, Mohamed-Saleh Rhim, Asma Boukadida, Dhekra Toumi, Raja Faleh, Noureddine Bouaouina, Abdelfatteh Zakhama, Elham Hassen Immunobiology. 2022 Mar;227(2):152189. doi: 10.1016/j.imbio.2022.152189. Epub 2022 Feb 16.
Background: Little is known about the relationship between arginase, an immunosuppressive enzyme, and cervical lesions. The present study is aimed at evaluating arginase activity in plasma and mRNA arginase isoforms expression in cervical cells of patients with abnormal cytology and identifying their relationship with Human papillomavirus (HPV) related parameters such as: HPV type, HPV circulating viral load and anti-HPV16 IgG. Methods: This study included 77 women with cervical lesions and 95 matched controls. Arginase activity was detected by colorimetric assay. Arginase mRNA expression and HPV viral load were evaluated by quantitative real time PCR and anti-HPV16 antibodies were assessed by ELISA. Results: Compared to controls, the arginase activity was higher among women with cervicitis / low grade squamous intraepithelial lesions (LSIL) (OR: 1.872, 95% CI: 0.833-4.210), and also among women with high-grade squamous intraepithelial lesions (HSIL) / squamous cell carcinoma (SCC) (OR: 3.358, 95% CI: 1.670-8.910). Compared to controls, mRNA expression was significantly upregulated in women with cervical cervicitis and SIL for ARG1, and in women with cancer lesions for ARG2. Arginase activity was positively correlated to ARG2 mRNA expression but not to ARG1. High arginase activity was associated with HPV16, high levels of HPV viral load, and low levels of anti-HPV16 antibodies. Conclusions: Our findings demonstrated that arginase activity and isoforms expression were enhanced in women with HPV-related precancerous lesions and cervical cancer. Further studies are needed to identify how arginase enzyme induces disease progression and severity.
2. ULTRASOUND DIAGNOSTICS OF CERVICAL CHANGES WITH DIFFERENT LOCALIZATION OF THE CERVICITIS IN WOMEN WITH THE ECTOPY OF THE VAGINAL PORTION OF THE CERVIX
R Abdullaiev, S Pavlov, F Kulikova, A Sibihankulov, M Medvediev, I Larionova, O Aleksenko Georgian Med News. 2019 May;(290):32-37.
The aim of the study was to improve the diagnosis of structural changes in all parts of the cervix depending on the preferential localization of the inflammatory process - in the ectocervix, endocervix, and also in the stroma in women with ectopia (pseudoerosis) of the vaginal part of the cervix. The study included women of predominantly early and middle reproductive age, as these women have inflammatory processes more often than in menopause. To perform the work, a transvaginal imaging method was used, which allowed us to see the smallest structures (up to 0.5-1.0 mm) of the cervix. We have previously developed a technique for visualizing the external part of the cervix and obtained a patent of Ukraine. The results of the ultrasound were compared with laboratory data, colposcopy and cervicoscopy. Traditionally, the diagnosis of cervicitis was made on the basis of clinical symptoms, smear results to determine the presence and type of pathogen. Endoscopic methods allowed visualization of only the mucous membrane of the cervical canal and external part of the cervix. The deep layers of the ectocervix, endocervix and cervical stroma can only be visualized using high-frequency ultrasound in a transvaginal way. According to the results of the study, it was possible to determine the preferential localization of the inflammatory process, to determine the nature of changes in different layers of the cervix. These changes were expressed in the presence of calcifications and cystic cavities of various sizes (1-6 mm), an increase or decrease in echogenicity, the degree of heterogeneity of the structure of the ecto-, endocervix and stroma.
3. CERVICITIS AS A CAUSE OF PRETERM BIRTH IN WOMEN
Aidyn G Salmanov, Volodymyr Artyomenko, Irina M Koctjuk, Nataliia V Mashyr, Oleg A Berestooy, Dzeneti Y Beraia Wiad Lek. 2022;75(11 pt 2):2715-2721. doi: 10.36740/WLek202211201.
Objective: The aim: To evaluate the prevalence of preterm birth and to determine the role of cervicitis as a cause of preterm birth in women in Ukraine. Patients and methods: Materials and methods: We conducted a retrospective multicentre cohort study from January 1st, 2019 to December 31st, 2021. This study included pregnant women aged 17-50 years admitted to the labor ward at the 13 hospitals from 10 regions of Ukraine. Results: Results: Of the 8151 participants, the prevalence of preterm birth was 2226 (27.3%, [95% CI 26.8 - 27.8]) whereas 5925 (72.7% [95% CI 72.2-73.2]) delivered at term. Preterm birth associated with cervicitis was 76.3% (4,388/2666). History of cervicitis, maternal age, previous preterm labor or premature birth, and pregnancy with twins, triplets or other multiples were identified as independent risk factors of preterm birth. Conclusion: Conclusions: Preterm birth in Ukraine is widespread, the number of which tends to increase. Infection and inflammation of the cervix seem to play a significant role for preterm birth. Early detection and treatment of cervicitis can reduce the risk of preterm birth. Women who have a history of poor pregnancy outcomes are at greater risk of poor outcomes in following pregnancies. Health providers should be aware of this risk when treating patients with a history of poor pregnancy outcomes.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
