Chlorogentisylquinone
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00307 |
| CAS | 333344-08-4 |
| Molecular Weight | 172.57 |
| Molecular Formula | C7H5ClO3 |
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Description
Chlorogentisylquinone is produced by the strain of FOM-8108. The IC50 of inhibitory rat meningeal nSMase was 1.2μmol/L, and the IC50 of P388 cells was 7.6μmol/L.
Specification
| Synonyms | 2,5-Cyclohexadiene-1,4-dione, 2-chloro-6-(hydroxymethyl)- |
| IUPAC Name | 2-chloro-6-(hydroxymethyl)cyclohexa-2,5-diene-1,4-dione |
| Canonical SMILES | C1=C(C(=O)C(=CC1=O)Cl)CO |
| InChI | InChI=1S/C7H5ClO3/c8-6-2-5(10)1-4(3-9)7(6)11/h1-2,9H,3H2 |
| InChI Key | AGIRBSHCJNCQAK-UHFFFAOYSA-N |
Properties
| Appearance | Brown Acicular Crystalline |
Reference Reading
1. Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus
R Uchida, H Tomoda, M Arai, S Omura J Antibiot (Tokyo). 2001 Nov;54(11):882-9. doi: 10.7164/antibiotics.54.882.
Chlorogentisylquinone, a new inhibitor of neutral sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including 1H, 13C, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral sphingomyelinase activity of rat brain membranes with an IC50 value of 1.2 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
