γ-Chloronorvaline
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| Category | Bioactive by-products |
| Catalog number | BBF-00637 |
| CAS | 76265-38-8 |
| Molecular Weight | 151.59 |
| Molecular Formula | C5H10ClNO2 |
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Description
γ-Chloronorvaline is produced by the strain of Streptomyces griseosporeus AL-719. It has the activity of resistance to Pseudomonas aeruginosa, Serrata, Klebsiella pneumoniae and Bacillus subtilis in the synthetic medium, but has no effect on Escherichia coli.
Specification
| Synonyms | gamma-Chloronorvaline; Antibiotic AL 719 |
| IUPAC Name | (2S,4S)-2-amino-4-chloropentanoic acid |
| Canonical SMILES | CC(CC(C(=O)O)N)Cl |
| InChI | InChI=1S/C5H10ClNO2/c1-3(6)2-4(7)5(8)9/h3-4H,2,7H2,1H3,(H,8,9)/t3-,4-/m0/s1 |
| InChI Key | RGNIDFUXHFKULB-IMJSIDKUSA-N |
Properties
| Appearance | Colorless Flake Crystalline |
| Antibiotic Activity Spectrum | fungi |
| Melting Point | 162-165 °C |
| Solubility | Soluble in Water |
Reference Reading
1. gamma-Chloronorvaline, a leucine analog from Streptomyces
S Narayanan, M R Iyengar, P L Ganju, S Rengaraju, T Shomura, T Tsuruoka, S Inouye, T Niida J Antibiot (Tokyo). 1980 Nov;33(11):1249-55. doi: 10.7164/antibiotics.33.1249.
gamma-Chloronorvaline (AL-719) and gamma-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with there respective configurations of (2S, 4S) and (2S, 4R). AL-719 shows antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
