Chrysospermin D
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-00333 |
| CAS | |
| Molecular Weight | 1914.24 |
| Molecular Formula | C91H144N22O23 |
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Description
It is produced by the strain of Apiocrea chrysosperma Ap101. Chrysospermin D has antibacterial activities against individual gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae).
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; yeast |
| Melting Point | 250 °C |
Reference Reading
1. Effective diameters of ion channels formed by homologs of the antibiotic chrysospermin
V I Ternovsky, P A Grigoriev, G N Berestovsky, R Schlegel, K Dornberger, U Gräfe Membr Cell Biol. 1997;11(4):497-505.
Radii of ion channels formed in the lipid bilayer by 4 homologs of the alamethicin-like antibiotic, chrysospermin, were determined using hydrophilic nonelectrolytes. It is shown that the replacement of isovaline amino acid at position 15 of the polypeptide chain by alpha-aminoisobutyric acid results in the decrease in the channel effective radius from 1.2 +/- 0.15 to 0.94 +/- 0.1 nm and a respective 2.5-fold decrease in channel conductance.
2. Chrysospermins, new peptaibol antibiotics from Apiocrea chrysosperma Ap101
K Dornberger, W Ihn, M Ritzau, U Gräfe, B Schlegel, W F Fleck, J W Metzger J Antibiot (Tokyo). 1995 Sep;48(9):977-89. doi: 10.7164/antibiotics.48.977.
Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
