CJ-14897
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| Category | Antibiotics |
| Catalog number | BBF-02771 |
| CAS | 377755-95-8 |
| Molecular Weight | 253.25 |
| Molecular Formula | C12H15NO5 |
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Description
It is originally isolated from Marasmiellus sp. CL21624. CJ-14897 inhibited human blood interleukin-1β (IL-1β) production induced by lipoglycan (LPS) with an IC50 of 0.059 μmol/L.
Specification
| Synonyms | (+)-CJ-14897; 2-Pyridinecarboxylic acid, 5-((1S,2S)-2-(acetyloxy)-1-hydroxypropyl)-, methyl ester; UNII-10M04QP59K |
| IUPAC Name | methyl 5-[(1S,2S)-2-acetyloxy-1-hydroxypropyl]pyridine-2-carboxylate |
| Canonical SMILES | CC(C(C1=CN=C(C=C1)C(=O)OC)O)OC(=O)C |
| InChI | InChI=1S/C12H15NO5/c1-7(18-8(2)14)11(15)9-4-5-10(13-6-9)12(16)17-3/h4-7,11,15H,1-3H3/t7-,11+/m0/s1 |
| InChI Key | CTJGPKROOIGCCC-WRWORJQWSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 405.1±40.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp
K Ichikawa, H Hirai, M Ishiguro, T Kambara, Y Kato, Y J Kim, Y Kojima, Y Matsunaga, H Nishida, Y Shiomi, N Yoshikawa, N Kojima J Antibiot (Tokyo). 2001 Sep;54(9):703-9. doi: 10.7164/antibiotics.54.703.
New cytokine production inhibitors, CJ-14,877 (I) and CJ-14,897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7S,8S)-5-(7,8-dihydroxypropyl)pyridine-2-carboxylate and methyl-(7S,8S)-5-(8-acetoxy-7-hydroxypropyl)pyridine-2-carboxylate [corrected], respectively, by spectroscopic analyses. These compounds showed inhibitory activities for lipopolysaccharide-induced production of interleukin-1beta and tumor necrosis factor-alpha in human whole blood with IC50 values of the range from 0.059 to 2.6 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
