CJ-17572
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| Category | Antibiotics |
| Catalog number | BBF-02781 |
| CAS | |
| Molecular Weight | 361.47 |
| Molecular Formula | C21H31NO4 |
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Description
It is produced by the strain of Pezicula sp. CJ-11877. CJ-17572 has anti-MRSA and Enterococcus faecalis activity with MIC of 10-20 μg/mL.
Specification
| Synonyms | 3-[hydroxy(1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methylidene]-5-(1-hydroxyethyl)-1-methylpyrrolidine-2,4-dione |
| IUPAC Name | 5-(1-hydroxyethyl)-3-[hydroxy-(1,2,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl)methylidene]-1-methylpyrrolidine-2,4-dione |
| Canonical SMILES | CC1CCC2C(C1)C=CC(C2(C)C(=C3C(=O)C(N(C3=O)C)C(C)O)O)C |
| InChI | InChI=1S/C21H31NO4/c1-11-6-9-15-14(10-11)8-7-12(2)21(15,4)19(25)16-18(24)17(13(3)23)22(5)20(16)26/h7-8,11-15,17,23,25H,6,9-10H2,1-5H3 |
| InChI Key | LVWQDHHIWXPCLH-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 548.6±50.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. A novel antibiotic CJ-17,572 from a fungus, Pezicula sp
Yutaka Sugie, Koen A Dekker, Taisuke Inagaki, Yoon-Jeong Kim, Tatsuo Sakakibara, Shinichi Sakemi, Akemi Sugiura, Lori Brennan, Joan Duignan, Joyce A Sutcliffe, Yasuhiro Kojima J Antibiot (Tokyo). 2002 Jan;55(1):19-24. doi: 10.7164/antibiotics.55.19.
A new antibiotic, CJ-17,572 (I) was isolated from the fermentation broth of a fungus Pezicula sp. CL11877. The structure of I was determined to be a new equisetin derivative by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant Staphylococcus aureus and Enterococcusfaecalis with IC50s of 10 and 20 microg/ml, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
