CJ-21164
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02785 |
| CAS | |
| Molecular Weight | 753.14 |
| Molecular Formula | C38H37ClO14 |
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Description
It is produced by the strain of Chloridium sp. CL48903. The IC50 of CJ-21164 inhibiting G6Pase in rat liver microsomes was 1.6 μmol/L.
Specification
| Synonyms | CHEMBL3218304 |
| IUPAC Name | 4-[4-[3-chloro-2-hydroxy-4-(1-hydroxy-2-methoxy-3,6-dimethyl-4-oxocyclohexa-2,5-diene-1-carbonyl)oxy-5,6-dimethylbenzoyl]oxy-2-hydroxy-3,6-dimethylbenzoyl]oxy-6-methoxy-2,3-dimethylbenzoic acid |
| Canonical SMILES | CC1=CC(=C(C(=C1C(=O)OC2=CC(=C(C(=C2C)C)C(=O)O)OC)O)C)OC(=O)C3=C(C(=C(C(=C3C)C)OC(=O)C4(C(=CC(=O)C(=C4OC)C)C)O)Cl)O |
| InChI | InChI=1S/C38H37ClO14/c1-14-11-23(21(8)30(41)26(14)35(45)52-24-13-25(49-9)27(34(43)44)17(4)16(24)3)51-36(46)28-18(5)19(6)32(29(39)31(28)42)53-37(47)38(48)15(2)12-22(40)20(7)33(38)50-10/h11-13,41-42,48H,1-10H3,(H,43,44) |
| InChI Key | AFEAZMLLVJMACB-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
Reference Reading
1. CJ-21,164, a new D-glucose-6-phosphate phosphohydrolase inhibitor produced by a fungus Chloridium sp
Yoon-Jeong Kim, Hiroyuki Nishida, Chang-Hong Pang, Toshiyuki Saito, Shinichi Sakemi, Hiroko Tonai-Kachi, Nobuji Yoshikawa, Maria A Vanvolkenburg, Janice C Parker, Yasuhiro Kojima J Antibiot (Tokyo). 2002 Feb;55(2):121-7. doi: 10.7164/antibiotics.55.121.
A new D-glucose-6-phosphate phosphohydrolase (G6Pase) inhibitor, CJ-21,164 (1) was isolated from the fermentation broth of the fungus Chloridium sp. CL48903. The structure was elucidated to be a novel tetramer of the salicylic acid derivatives by spectroscopic analyses. Compound I inhibited G6Pase in rat liver microsomes with an IC50 of 1.6 microM. Glucose output from hepatocytes isolated from rat liver was inhibited when I was present in the incubation medium, consistent with the role of I as a G6Pase inhibitor.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
