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Clavariopsin A

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Category Antibiotics
Catalog number BBF-00361
CAS
Molecular Weight 1154.43
Molecular Formula C59H95N9O14

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Clavariopsis aquatica AJ117363. Clavariopsin A has anti-candida albicans, Aspergillus fumigata and Aspergillus Niger activity, and has little effect on bacteria.

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Synonyms Clarvariopsin A; 2-{(4S,7S,10S,13S,16S,22S,25S,28R)-3,6,9,12,15,18,21,24,30-Nonaaza-13,16-bis((1S)-1-methylpropyl)-25-[(4-methoxyphenyl)methyl]-3,9,12,15,21-pentamethyl-27-oxa-2,5,8,11,14,17,20,23,26,29-decaoxo-4,7,22,28-tetrakis(methylethyl)bicyclo[28.4.0]tetratriacont-10-yl}acetic acid
IUPAC Name 2-[(3R,6S,9S,15S,18S,21S,24S,27S,30S)-15,18-bis[(2S)-butan-2-yl]-6-[(4-methoxyphenyl)methyl]-10,16,19,22,28-pentamethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-3,9,24,27-tetra(propan-2-yl)-4-oxa-1,7,10,13,16,19,22,25,28-nonazabicyclo[28.4.0]tetratriacontan-21-yl]acetic acid
Canonical SMILES CCC(C)C1C(=O)NCC(=O)N(C(C(=O)NC(C(=O)OC(C(=O)N2CCCCC2C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)CC)C)CC(=O)O)C)C(C)C)C(C)C)C)C(C)C)CC3=CC=C(C=C3)OC)C(C)C)C
InChI InChI=1S/C59H95N9O14/c1-19-36(11)48-51(72)60-31-43(69)64(14)46(33(5)6)52(73)61-40(29-38-24-26-39(81-18)27-25-38)59(80)82-50(35(9)10)58(79)68-28-22-21-23-41(68)54(75)65(15)47(34(7)8)53(74)62-45(32(3)4)56(77)63(13)42(30-44(70)71)55(76)67(17)49(37(12)20-2)57(78)66(48)16/h24-27,32-37,40-42,45-50H,19-23,28-31H2,1-18H3,(H,60,72)(H,61,73)(H,62,74)(H,70,71)/t36-,37-,40-,41-,42-,45-,46-,47-,48-,49-,50+/m0/s1
InChI Key ALFBBRGNEWVYDN-DLXPCLOVSA-N
Appearance Colorless Powder
Antibiotic Activity Spectrum fungi
1. New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties
K Kaida, R Fudou, T Kameyama, K Tubaki, Y Suzuki, M Ojika, Y Sakagami J Antibiot (Tokyo). 2001 Jan;54(1):17-21. doi: 10.7164/antibiotics.54.17.
Clavariopsins were isolated from the fermentation broth of Clavariopsis aquatica AJ 117363. Clavariopsins are cyclic depsipeptide antibiotics with the molecular weight of 1,153 and 1,139. Clavariopsins showed in vitro antifungal activity against not only Aspergillus fumigatus but also, although to a lesser extent, A. niger and Candida albicans.

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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