Clavariopsin A
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| Category | Antibiotics |
| Catalog number | BBF-00361 |
| CAS | |
| Molecular Weight | 1154.43 |
| Molecular Formula | C59H95N9O14 |
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Description
It is produced by the strain of Clavariopsis aquatica AJ117363. Clavariopsin A has anti-candida albicans, Aspergillus fumigata and Aspergillus Niger activity, and has little effect on bacteria.
Specification
| Synonyms | Clarvariopsin A; 2-{(4S,7S,10S,13S,16S,22S,25S,28R)-3,6,9,12,15,18,21,24,30-Nonaaza-13,16-bis((1S)-1-methylpropyl)-25-[(4-methoxyphenyl)methyl]-3,9,12,15,21-pentamethyl-27-oxa-2,5,8,11,14,17,20,23,26,29-decaoxo-4,7,22,28-tetrakis(methylethyl)bicyclo[28.4.0]tetratriacont-10-yl}acetic acid |
| IUPAC Name | 2-[(3R,6S,9S,15S,18S,21S,24S,27S,30S)-15,18-bis[(2S)-butan-2-yl]-6-[(4-methoxyphenyl)methyl]-10,16,19,22,28-pentamethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-3,9,24,27-tetra(propan-2-yl)-4-oxa-1,7,10,13,16,19,22,25,28-nonazabicyclo[28.4.0]tetratriacontan-21-yl]acetic acid |
| Canonical SMILES | CCC(C)C1C(=O)NCC(=O)N(C(C(=O)NC(C(=O)OC(C(=O)N2CCCCC2C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)CC)C)CC(=O)O)C)C(C)C)C(C)C)C)C(C)C)CC3=CC=C(C=C3)OC)C(C)C)C |
| InChI | InChI=1S/C59H95N9O14/c1-19-36(11)48-51(72)60-31-43(69)64(14)46(33(5)6)52(73)61-40(29-38-24-26-39(81-18)27-25-38)59(80)82-50(35(9)10)58(79)68-28-22-21-23-41(68)54(75)65(15)47(34(7)8)53(74)62-45(32(3)4)56(77)63(13)42(30-44(70)71)55(76)67(17)49(37(12)20-2)57(78)66(48)16/h24-27,32-37,40-42,45-50H,19-23,28-31H2,1-18H3,(H,60,72)(H,61,73)(H,62,74)(H,70,71)/t36-,37-,40-,41-,42-,45-,46-,47-,48-,49-,50+/m0/s1 |
| InChI Key | ALFBBRGNEWVYDN-DLXPCLOVSA-N |
Properties
| Appearance | Colorless Powder |
| Antibiotic Activity Spectrum | fungi |
Reference Reading
1. New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties
K Kaida, R Fudou, T Kameyama, K Tubaki, Y Suzuki, M Ojika, Y Sakagami J Antibiot (Tokyo). 2001 Jan;54(1):17-21. doi: 10.7164/antibiotics.54.17.
Clavariopsins were isolated from the fermentation broth of Clavariopsis aquatica AJ 117363. Clavariopsins are cyclic depsipeptide antibiotics with the molecular weight of 1,153 and 1,139. Clavariopsins showed in vitro antifungal activity against not only Aspergillus fumigatus but also, although to a lesser extent, A. niger and Candida albicans.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
