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Clavicoronic acid

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Category Enzyme inhibitors
Catalog number BBF-00363
CAS 139748-98-4
Molecular Weight 262.30
Molecular Formula C15H18O4

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Clavicoronic acid is produced by the strain of Clavicorona pyxidata. It can inhibit the reverse transcriptase activity of myeloblastocytosis virus (AMV) and Moloney mouse leukemia virus (MMuLV).

  • Specification
  • Properties
  • Reference Reading
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Synonyms (6-Formyl-2,2,4-trimethyl-2,3,3a,7a-tetrahydro-1H-inden-5-yl)(oxo)acetic acid; 1H-Indene-5-acetic acid, 6-formyl-2,3,3a,7a-tetrahydro-2,2,4-trimethyl-alpha-oxo-, (3aS-cis)-
IUPAC Name 2-[(3aS)-6-formyl-2,2,4-trimethyl-1,3,3a,7a-tetrahydroinden-5-yl]-2-oxoacetic acid
Canonical SMILES CC1=C(C(=CC2C1CC(C2)(C)C)C=O)C(=O)C(=O)O
InChI InChI=1S/C15H18O4/c1-8-11-6-15(2,3)5-9(11)4-10(7-16)12(8)13(17)14(18)19/h4,7,9,11H,5-6H2,1-3H3,(H,18,19)/t9?,11-/m1/s1
InChI Key FUUQWZJSFLVSPA-HCCKASOXSA-N
Appearance White Powder
Antibiotic Activity Spectrum viruses
Melting Point 75-77 °C
1. Antibiotics from basidiomycetes. XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty
G Erkel, T Anke, A Gimenez, W Steglich J Antibiot (Tokyo). 1992 Jan;45(1):29-37. doi: 10.7164/antibiotics.45.29.
A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 microM) and Moloney murine leukemia virus (Ki 68 microM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

Bio Calculators

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Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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