Clavicoronic acid
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00363 |
| CAS | 139748-98-4 |
| Molecular Weight | 262.30 |
| Molecular Formula | C15H18O4 |
Online Inquiry
Description
Clavicoronic acid is produced by the strain of Clavicorona pyxidata. It can inhibit the reverse transcriptase activity of myeloblastocytosis virus (AMV) and Moloney mouse leukemia virus (MMuLV).
Specification
| Synonyms | (6-Formyl-2,2,4-trimethyl-2,3,3a,7a-tetrahydro-1H-inden-5-yl)(oxo)acetic acid; 1H-Indene-5-acetic acid, 6-formyl-2,3,3a,7a-tetrahydro-2,2,4-trimethyl-alpha-oxo-, (3aS-cis)- |
| IUPAC Name | 2-[(3aS)-6-formyl-2,2,4-trimethyl-1,3,3a,7a-tetrahydroinden-5-yl]-2-oxoacetic acid |
| Canonical SMILES | CC1=C(C(=CC2C1CC(C2)(C)C)C=O)C(=O)C(=O)O |
| InChI | InChI=1S/C15H18O4/c1-8-11-6-15(2,3)5-9(11)4-10(7-16)12(8)13(17)14(18)19/h4,7,9,11H,5-6H2,1-3H3,(H,18,19)/t9?,11-/m1/s1 |
| InChI Key | FUUQWZJSFLVSPA-HCCKASOXSA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | viruses |
| Melting Point | 75-77 °C |
Reference Reading
1. Antibiotics from basidiomycetes. XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty
G Erkel, T Anke, A Gimenez, W Steglich J Antibiot (Tokyo). 1992 Jan;45(1):29-37. doi: 10.7164/antibiotics.45.29.
A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 microM) and Moloney murine leukemia virus (Ki 68 microM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
