Clavulanate Potassium (1:1 mixture with silicon dioxide)
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03915 |
| CAS | 61177-45-5 |
| Molecular Weight | 237.25 |
| Molecular Formula | C8H8KNO5 |
| Purity | 91.2 % - 107.1 % |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-03915 | 10 g | $199 | In stock |
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Clavulanate Potassium is a semi-synthetic beta-lactamase inhibitor isolated from streptomyces. It contains a beta-lactam ring and binds strongly to beta-lactamase at or near its active site. It is used in conjunction with beta-lactamase susceptible penicillins to treat infections caused by beta-lactamase producing organisms. It is commonly combined with amoxicillin or ticarcillin to increase its effectiveness.
Specification
| Related CAS | 57943-81-4 (sodium) 58001-44-8 (free acid) |
| Synonyms | Amonate; MM-14151; MM14151 |
| Storage | Store at -20°C, Under Inert Atmosphere |
| IUPAC Name | potassium;(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Canonical SMILES | C1C2N(C1=O)C(C(=CCO)O2)C(=O)[O-].[K+] |
| InChI | InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1 |
| InChI Key | ABVRVIZBZKUTMK-JSYANWSFSA-M |
| Source | Streptomyces sp. |
Properties
| Appearance | Yellow to Brownish Orange Solid |
| Application | beta-Lactamase Inhibitors |
| Boiling Point | 545.8°C at 760 mmHg |
| Melting Point | >170°C |
| Solubility | Soluble in Methanol, Water |
Reference Reading
1.Results from the Survey of Antibiotic Resistance (SOAR) 2002-09 in Turkey.
Torumkuney D1, Gur D2, Soyletir G3, Gurler N4, Aktas Z4, Sener B2, Tunger A5, Bayramoglu G6, Koksal I6, Yalcin AN7, Tanriver Y8, Morrissey I9, Barker K10. J Antimicrob Chemother. 2016 May;71 Suppl 1:i85-i91. doi: 10.1093/jac/dkw067.
OBJECTIVES: To investigate changes in antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from the Survey of Antibiotic Resistance (SOAR) in community-acquired respiratory tract infections (CA-RTIs) between 2002 and 2009 in Turkey.
2.Phenotypic Tests for the Detection of β-Lactamase-Producing Enterobacteriaceae Isolated from Different Environments.
de Oliveira DV1, Van Der Sand ST2. Curr Microbiol. 2016 Apr 12. [Epub ahead of print]
Some bacteria from the Enterobacteriaceae family are showing a significant capability to disseminate β-lactams resistance mechanisms among them, and these same mechanisms can be carried out from the hospital environment to superficial water. The aim of this study was to evaluate different phenotypic methods for the detection β-lactamases production by enterobacteria isolated from the anthropogenic environment: hospital wastewater and from a stream that cross the city of Porto Alegre. The applied tests were the modified Hodge test (MHT) and phenotypic tests with the following inhibitors: carbapenemase-phenylboronic acid (APB), metallo-β-lactamase-EDTA, AmpC β-lactamase-cloxacillin, and the confirmatory test for extended-spectrum β-lactamase (ESBL)-clavulanic acid. For this evaluation, 131 isolates were initially subjected to antibiogram using the following antimicrobials: cefotaxime (30 µg), cefpodoxime (10 μg), ceftazidime (30 µg), ertapenem (10 μg), meropenem (10 μg), and aztreonam (30 μg).
3.[Cutaneous larva migrans: report of three cases from the Western Black Sea Region, Turkey].
Çalışkan E1, Uslu E, Turan H, Başkan E, Kılıç N. Mikrobiyol Bul. 2016 Jan;50(1):165-9.
Cutaneous larva migrans (CLM) is a parasitosis frequently seen in persons who have travelled to tropical or subtropical regions and in those who have worked in contact with soil. The disease frequently develops due to Ancylostoma braziliensis and Ancylostoma caninum species. After penetrating the skin and entering the body, the hookworm larva proceeds to bore tunnels through the epidermis, creating pruritic, erythematous, serpiginous lesions. Secondary bacterial infections of the lesions can often be seen, especially on the legs and buttocks. In this article we presented three atypical local cases which have not been declared previously in our country. The first case, a 54-year-old male who was admitted to hospital in August with complaints of an obverse body rash and itching lasting for a week. Eruptions were observed over a small area on the right side of the abdomen, consisting of itchy, raised, erythematous, curvilinear string-like lesions.
4.Antibiotic overusage and resistance: A cross-sectional survey among pediatric dentists.
Konde S1, Jairam LS, Peethambar P, Noojady SR, Kumar NC. J Indian Soc Pedod Prev Dent. 2016 Apr-Jun;34(2):145-51. doi: 10.4103/0970-4388.180444.
INTRODUCTION: Most human orofacial infections originate from odontogenic infections and prescribing antibiotics has become a ubiquitous phenomenon. The World Health Organization (WHO) has recognized the inappropriate, indiscriminate, and irrational use of antibiotics leading to antibiotic resistance as a global problem.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
