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Clindamycin 2-Phosphate

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Clindamycin 2-Phosphate
Category Antibiotics
Catalog number BBF-04542
CAS 24729-96-2
Molecular Weight 504.96
Molecular Formula C18H34ClN2O8PS
Purity Content:≥ 758 µg/mg
Catalog Number Size Price Stock Quantity
BBF-04542 100 g $279 In stock

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Product Description

Clindamycin Phosphate is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM. It is usually used to treat infections with anaerobic bacteria, but can also be used to treat protozoal diseases, such as malaria. It is a common drug used to treat topical acne and can be effective against some methicillin-resistant Staphylococcus aureus (MRSA) infections. An impurity of Clindamycin.

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Synonyms Methyl 7-Chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidine-carboxamido)-1-thio-L-threo-α-D-galactooctopyranoside 2-(Dihydrogen Phosphate); 7(S)-Chloro-7-deoxylincomycin 2-Phosphate; Cleocin T; Cleocin Phosphate; Clinadac; Clindagel; Clindesse; Clindets; Dalacin P; Dalacin T; NSC 618653
Storage Store at 2-8°C under inert atmosphere
IUPAC Name [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
Canonical SMILES CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)OP(=O)(O)O)O)O)C(C)Cl
InChI InChI=1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1
InChI Key UFUVLHLTWXBHGZ-MGZQPHGTSA-N
Source Semi-synthetic
Appearance White Solid
Antibiotic Activity Spectrum Gram-positive bacteria
Boiling Point 159°C
Melting Point 187-192°C (dec.)
Density 1.41±0.1 g/cm3 (Predicted)
Solubility Soluble in DMSO (Slightly), Methanol (Slightly, Heated)
1.Clindamycin Phosphate Absorption from Nanoliposomal Formulations through Third-Degree Burn Eschar.
Ghaffari A1, Manafi A2, Moghimi HR3. World J Plast Surg. 2015 Jul;4(2):145-52.
BACKGROUND: It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption; there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from liposomal formulations to answer this question. In this investigation, permeation of CP through fully hydrated third-degree burn eschar was evaluated using solution, normal nanoliposomes and ultradeformable nanoliposomes.
2.Randomized, Observer-blind, Split-face Compatibility Study with Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% gel and Facial Foundation Makeup.
Bhatia N1, Pillai R2. J Clin Aesthet Dermatol. 2015 Sep;8(9):25-32.
BACKGROUND: Cosmetic compatibility in the treatment of acne is an important issue significantly impacting quality of life, but often overlooked, as dermatologists commonly recommended avoidance of cosmetic foundations when treating adult female patients. Fixed combinations of clindamycin/benzoyl peroxide are widely used in the treatment of acne, but little is known about the impact of their concomitant use with facial foundation.
3.Efficacy, tolerability and impact on quality of life of clindamycin phosphate and benzoyl peroxide for the treatment of cetuximab-associated acneiform eruption in patients with metastatic colorectal cancer.
Vaccaro M1, Guarneri F1, Borgia F1, Pollicino A2, Altavilla G2, Cannavò SP1. J Dermatolog Treat. 2016 Mar;27(2):148-52. doi: 10.3109/09546634.2015.1086478. Epub 2015 Sep 24.
BACKGROUND: Epidermal growth factor receptor inhibitors are recent antineoplastic treatments used for the treatment of some non-cutaneous tumours, which aberrantly express EGFR. Because of their specificity, these drugs have low systemic toxicity, but frequent undesired cutaneous effects, the most common of which is an acneiform eruption, occurring after 1-3 weeks of treatment. Management of this rash is not well standardized.

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