Clomocycline
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| Category | Bioactive by-products |
| Catalog number | BBF-00651 |
| CAS | 1181-54-0 |
| Molecular Weight | 508.91 |
| Molecular Formula | C23H25ClN2O9 |
| Purity | 95% |
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Description
It is produced by the strain of Streptomyces aureofaciens. Clomocycline has anti-gram-positive and negative bacteria activity.
Specification
| Synonyms | Chlormethylenecycline; N'-Methylolo-chlortetracycline; 7-Chloro-N-(hydroxymethyl)tetracycline; Megaclor |
| IUPAC Name | (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide |
| Canonical SMILES | CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)NCO)N(C)C)O |
| InChI | InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-29,32,34-35H,6-7H2,1-3H3,(H,25,33)/t8-,9-,16-,22-,23-/m0/s1 |
| InChI Key | BXTHDFJCJQJHKD-KMVLDZISSA-N |
Properties
| Appearance | Yellow Amorphous Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 739.7°C at 760 mmHg |
| Melting Point | 154-170 °C |
| Density | 1.70 g/cm3 |
Reference Reading
1.A clinical trial of clomocycline in general practice.
Marshall BU. Practitioner. 1966 Sep;197(179):362-4.
2.Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not.
Potts RC, MacConnachie A, Brown RA, Gibbs JH, Robertson AJ, Hassan HA, Beck JS. Br J Clin Pharmacol. 1983 Aug;16(2):127-32.
Eight tetracycline drugs were tested for inhibitory effect on phytohaemagglutinin (PHA) stimulated growth (measured by [3H]-TdR uptake) of peripheral blood mononuclear cells: at least 26 normal subjects were tested with each drug. Doxycycline reduced DNA synthesis appreciably at concentrations within and just above the therapeutic range of blood levels: it was the most potent inhibitor, but demeclocycline, methacycline and minocycline had similar, if less potent, effects. Tetracycline, oxytetracycline, chlortetracycline and clomocycline did not inhibit DNA synthesis of 3-day cultures even at concentrations five to ten times greater than the therapeutic blood level. Volume spectroscopy measurements showed that none of the eight tetracycline drugs interfered with the recruitment of cells into G1-phase growth of the first cell cycle after PHA stimulation.
3.Clomocycline and oxytetracycline in acne vulgaris.
Ganpule M. Practitioner. 1968 Sep;201(203):479-82.
4.Clinical trial of clomocycline (Megaclor) in gonococcal and non-gonococcal urethritis.
Andrew GS, Edwards JC, Oller LZ. Br J Vener Dis. 1969 Jun;45(2):154-6.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
