Cloxacillin Sodium Monohydrate
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| Category | Antibiotics |
| Catalog number | BBF-04038 |
| CAS | 7081-44-9 |
| Molecular Weight | 475.88 |
| Molecular Formula | C19H19ClN3NaO6S |
| Purity | >98% |
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Description
Cloxacillin Sodium Monohydrate is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.
Specification
| Related CAS | 61-72-3 (Free Acid) |
| Synonyms | Cloxapen |
| Storage | Store at 2-8°C |
| IUPAC Name | sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate |
| Canonical SMILES | CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+] |
| InChI | InChI=1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1./s1 |
| InChI Key | KCUWTKOTPIUBRI-VICXVTCVSA-M |
| Source | Semi-synthetic |
Properties
| Appearance | White Powder |
| Application | Anti-Bacterial Agents |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 689.7°C at 760 mmHg |
Reference Reading
1.Surveillance of Quality of Medicines Available in the Nepalese Market: A Study from Kathmandu Valley.
Gyanwali P1, Humagain BR2, Aryal KK1, Pandit A1, Acharya T1, Bista B1, Dhimal M1, Karki KB1. J Nepal Health Res Counc. 2015 Sep;13(31):233-40.
BACKGROUND: Many countries are having problem of substandard and counterfeit drugs which results in life threatening issues, financial loss of consumers and loss in trust on health system. This study is concerned with the assessment of drugs quality available in the Nepalese market.
2.Bacteriological Profile of Neonatal Sepsis in Neonatal Intermediate Care Unit of Central Paediatric Referral Hospital in Nepal.
Chapagain RH1, Acharya R2, Shrestha N2, Giri BR2, Bagale BB2, Kayastha M2. J Nepal Health Res Counc. 2015 Sep;13(31):205-8.
BACKGROUND: Sepsis is one of the leading causes of neonatal morbidity and mortality. Because of difference in local epidemiology and possible variation with time, regular monitoring and updates on pathogen and their antimicrobial sensitivity pattern is important for prevention and treatment.
3.Phenotypic Tests for the Detection of β-Lactamase-Producing Enterobacteriaceae Isolated from Different Environments.
de Oliveira DV1, Van Der Sand ST2. Curr Microbiol. 2016 Apr 12. [Epub ahead of print]
Some bacteria from the Enterobacteriaceae family are showing a significant capability to disseminate β-lactams resistance mechanisms among them, and these same mechanisms can be carried out from the hospital environment to superficial water. The aim of this study was to evaluate different phenotypic methods for the detection β-lactamases production by enterobacteria isolated from the anthropogenic environment: hospital wastewater and from a stream that cross the city of Porto Alegre. The applied tests were the modified Hodge test (MHT) and phenotypic tests with the following inhibitors: carbapenemase-phenylboronic acid (APB), metallo-β-lactamase-EDTA, AmpC β-lactamase-cloxacillin, and the confirmatory test for extended-spectrum β-lactamase (ESBL)-clavulanic acid. For this evaluation, 131 isolates were initially subjected to antibiogram using the following antimicrobials: cefotaxime (30 µg), cefpodoxime (10 μg), ceftazidime (30 µg), ertapenem (10 μg), meropenem (10 μg), and aztreonam (30 μg).
4.Significant Pharmacokinetic Interactions Between Quinine and Ampicillin-Cloxacillin Combination.
Falade OB1, Falusi AG2, Olaniyi AA1, Ezeasor C3, Kwasi DA1, Babalola CP4,5. Drugs R D. 2016 Mar 28. [Epub ahead of print]
INTRODUCTION: The co-existence of malaria with bacterial infections is common in the tropics, hence the concurrent use of antimalarials and antibiotics.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
