Cororubicin
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| Category | Antibiotics |
| Catalog number | BBF-01063 |
| CAS | 160605-92-5 |
| Molecular Weight | 1003.00 |
| Molecular Formula | C48H62N2O21 |
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Description
It is produced by the strain of Micromonospora sp. JY16. It has anti-tumor cell activity. The IC50 of KB cells and N18-RE-105 cells was 4.3 X 10-6 mol/L and 0.84 X 10-6 mol/L, respectively.
Specification
| IUPAC Name | methyl 24-[5-[5-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-4,6-dimethyl-4-nitrooxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-23-(dimethylamino)-4,8,12,22-tetrahydroxy-1,12-dimethyl-6,17-dioxo-20,25-dioxahexacyclo[19.3.1.02,19.05,18.07,16.09,14]pentacosa-2,4,7(16),8,14,18-hexaene-13-carboxylate |
| Canonical SMILES | CC1C(C(CC(O1)OC2C(OC(CC2(C)[N+](=O)[O-])OC3C(OC(CC3O)OC4C(C(C5OC6=C7C(=C(C=C6C4(O5)C)O)C(=O)C8=C(C7=O)C=C9C(C(CCC9=C8O)(C)O)C(=O)OC)O)N(C)C)C)C)O)O |
| InChI | InChI=1S/C48H62N2O21/c1-17-35(54)25(52)14-27(64-17)68-42-19(3)66-29(16-46(42,4)50(61)62)67-40-18(2)65-28(15-26(40)53)69-43-34(49(7)8)39(58)45-70-41-23(48(43,6)71-45)13-24(51)31-32(41)37(56)22-12-21-20(36(55)30(22)38(31)57)10-11-47(5,60)33(21)44(59)63-9/h12-13,17-19,25-29,33-35,39-40,42-43,45,51-55,58,60H,10-11,14-16H2,1-9H3 |
| InChI Key | MSWPFMVQHLUEJE-UHFFFAOYSA-N |
Properties
| Appearance | Orange Powder |
| Antibiotic Activity Spectrum | Neoplastics (Tumor) |
| Melting Point | 192-194 °C |
| Density | 1.54 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Cororubicin, a new anthracycline antibiotic generating active oxygen in tumor cells
K Ishigami, Y Hayakawa, H Seto J Antibiot (Tokyo). 1994 Nov;47(11):1219-25. doi: 10.7164/antibiotics.47.1219.
In the course of our screening for antitumor antibiotics which show biological activities by generating active oxygen in tumor cells. Micromonospora sp. JY16 was found to produce a new anthracycline antibiotic designated cororubicin. The structure of cororubicin was elucidated as shown in Fig. 5 on the basis of NMR spectral analysis. Cororubicin generated superoxide radicals in tumor cells and showed cytotoxicity, which was reduced by addition of an antioxidative agent, dithiothreitol (DTT).
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
