Cycloviracin B2
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-01125 |
| CAS | 142382-46-5 |
| Molecular Weight | 1676.06 |
| Molecular Formula | C83H150O33 |
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Description
Cycloviracin B2 is produced by the strain of Kibdelosporangium albatum sp. R761-7. It has anti-herpes simplex virus Type I (HSV-1) activity and has weak anti-gram-positive bacterial activity.
Specification
| IUPAC Name | (1S,3R,8R,9S,10S,11S,12R,14R,19S,20S,21R,22S)-3-((16R)-16,22-bis(((2S,3R,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)oxy)tricosyl)-14-(14-(((2S,3R,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-yl)oxy)-20-oxohenicosyl)-9,10,11,20,21,22-hexahydroxy-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.18,12]tetracosane-5,16-dione |
Properties
| Appearance | Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Viruses |
| Melting Point | 82-83 °C |
| Solubility | Soluble in Methanol, DMSO |
Reference Reading
1. New antiviral antibiotics, cycloviracins B1 and B2. I. Production, isolation, physico-chemical properties and biological activity
M Tsunakawa, N Komiyama, O Tenmyo, K Tomita, K Kawano, C Kotake, M Konishi, T Oki J Antibiot (Tokyo). 1992 Sep;45(9):1467-71. doi: 10.7164/antibiotics.45.1467.
Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B1 and B2. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B1 and B2 by degradation and spectroscopic analysis.
2. Kibdelosporangium albatum sp. nov., producer of the antiviral antibiotics cycloviracins
K Tomita, Y Hoshino, T Miyaki Int J Syst Bacteriol. 1993 Apr;43(2):297-301. doi: 10.1099/00207713-43-2-297.
A new species of the genus Kibdelosporangium is described. This soil organism forms long straight spore chains and numerous sporangium-like structures on the aerial mycelium. The new species has type IV cell walls and pattern A whole-cell sugars (meso-diaminopimelic acid, arabinose, and galactose are present), type PII phospholipids, MK-9(H4) as the major menaquinone, and no mycolic acids. On the basis of morphology and chemotaxonomy, the single isolate is assigned to the genus Kibdelosporangium. The isolate differs from two previously described species of the genus in fatty acid composition, the absence of melanin formation, and many physiological and biochemical characteristics and is identified as a new species. Accordingly, the name Kibdelosporangium albatum sp. nov. is proposed for this isolate. The type strain is R761-7 (= ATCC 55061).
3. New antiviral antibiotics, cycloviracins B1 and B2. II. Structure determination
M Tsunakawa, C Kotake, T Yamasaki, T Moriyama, M Konishi, T Oki J Antibiot (Tokyo). 1992 Sep;45(9):1472-80. doi: 10.7164/antibiotics.45.1472.
The structures of novel antiviral antibiotics, cycloviracins B1 and B2 have been determined by means of chemical and spectroscopic methods including 2D NMR correlation spectroscopy. The antibiotics are unique macrocyclic diesters consisting of two D-glucoses, three 2-O-methyl-D-glucoses and two (C24 and C26) hydroxy fatty acids.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
