Cytosporin A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00770 |
| CAS | |
| Molecular Weight | 308.37 |
| Molecular Formula | C17H24O5 |
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Description
Cytosporin A is an angiotensin II receptor antagonist produced by Cytospora sp. Cytosporin A selectively inhibits the binding of angiotensin II to the AT2 site of the receptor with IC50 of 1.5-3.0 mol/L (0.5 to 1 μg/mL).
Specification
| IUPAC Name | (1aS,4aR,7R,8aS)-7-hydroxy-6,6-dimethyl-2-oxo-3-pentyl-1a,4a,7,8-tetrahydrooxireno[2,3-e]chromene-4-carbaldehyde |
| Canonical SMILES | CCCCCC1=C(C2C3(CC(C(O2)(C)C)O)C(C1=O)O3)C=O |
| InChI | InChI=1S/C17H24O5/c1-4-5-6-7-10-11(9-18)14-17(15(22-17)13(10)20)8-12(19)16(2,3)21-14/h9,12,14-15,19H,4-8H2,1-3H3/t12-,14-,15-,17+/m1/s1 |
| InChI Key | ODZUPGUSIOTTSS-MMTVNHQJSA-N |
Reference Reading
1. Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures
S Stevens-Miles, M A Goetz, G F Bills, R A Giacobbe, J S Tkacz, R S Chang, M Mojena, I Martin, M T Diez, F Pelaez, O D Hensens, T Jones, R W Burg, Y L Kong, L Huang J Antibiot (Tokyo). 1996 Feb;49(2):119-23. doi: 10.7164/antibiotics.49.119.
Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
