Cytosporin B
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| Category | Bioactive by-products |
| Catalog number | BBF-00771 |
| CAS | |
| Molecular Weight | 346.85 |
| Molecular Formula | C17H27ClO5 |
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Description
Cytosporin B is a minor component produced by Cytospora sp.
Specification
| IUPAC Name | (3R,4aS,5R,6S,8aR)-5-chloro-3,4a,6-trihydroxy-2,2-dimethyl-7-pentyl-4,5,6,8a-tetrahydro-3H-chromene-8-carbaldehyde |
| Canonical SMILES | CCCCCC1=C(C2C(CC(C(O2)(C)C)O)(C(C1O)Cl)O)C=O |
| InChI | InChI=1S/C17H27ClO5/c1-4-5-6-7-10-11(9-19)15-17(22,14(18)13(10)21)8-12(20)16(2,3)23-15/h9,12-15,20-22H,4-8H2,1-3H3/t12-,13+,14-,15-,17-/m1/s1 |
| InChI Key | YSYMCIKNYHKBHZ-JRBZFYFNSA-N |
Reference Reading
1. Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures
S Stevens-Miles, M A Goetz, G F Bills, R A Giacobbe, J S Tkacz, R S Chang, M Mojena, I Martin, M T Diez, F Pelaez, O D Hensens, T Jones, R W Burg, Y L Kong, L Huang J Antibiot (Tokyo). 1996 Feb;49(2):119-23. doi: 10.7164/antibiotics.49.119.
Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.
2. Nuclear Receptor Subfamily 4 Group A Member 1 Overexpression Prolongs Free Flap Allotransplant Graft Survival by Inducing T-Cell Anergy in the Rat
Bo Xiao, Yanqun Zhang, Shiqiang Liu, Jianke Ding, Zhou Yu, Tong Wang, Baoqiang Song Transplant Proc. 2021 Jan-Feb;53(1):474-480. doi: 10.1016/j.transproceed.2020.08.023. Epub 2020 Sep 9.
Background: New strategies to inhibit acute rejection are needed for further applications of composite tissue allotransplantation. The nuclear receptor subfamily 4 group A member 1 (NR4A1) is considered a key controller of maintaining tolerance homeostasis. However, the effect of NR4A1 in suppressing rejection responses after allotransplantation remains unknown. Methods: Brown Norway rat groin flaps were transplanted into Lewis rat recipients. The recipients were administrated cytosporone B, an NR4A1 activator. NR4A1 expression and graft survival time were assessed. T helper type 1 and regulatory T cell populations in the second lymphoid organ were detected by flow cytometry. Furthermore, a retrovirus containing NR4A1 was constructed and transfected to T cells in vitro. After stimulation, interleukin 2 and interferon gamma secretions were detected in the T cells. Results: Administration of cytosporone B activated NR4A1 expression in allotransplant recipients and was associated with prolonged survival time of the vascularized free flap allograft. T helper type 1 cells in the recipient secondary lymphoid organs were decreased, whereas the population of regulatory T cells did not change. Interleukin 2 and interferon gamma were suppressed in vitro in the T cells overexpressing NR4A1. Conclusions: We demonstrated that the overexpressed NR4A1 is associated with suppressed graft rejection response. The suppression effect may attribute to induction of T-cell anergy and blockade of key immunologic cytokines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
