DC 86M
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| Category | Antibiotics |
| Catalog number | BBF-02803 |
| CAS | 94448-15-4 |
| Molecular Weight | 326.30 |
| Molecular Formula | C17H14N2O5 |
| Purity | >98% |
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Description
It is originally isolated from Streptomyces lugeogriseus 86. DC 86M has anti-Gram-positive bacteria and weak anti-Gram-negative bacteria activity, and can inhibit mouse sarcoma 180 cells.
Specification
| Synonyms | 6-(1-((Hydroxyacetyl)oxy)ethyl)-1-phenazinecarboxylic acid; DC-86-M; DC-86M; DC 86 M; 6-{1-[(Hydroxyacetyl)oxy]ethyl}phenazine-1-carboxylic acid |
| IUPAC Name | 6-[1-(2-hydroxyacetyl)oxyethyl]phenazine-1-carboxylic acid |
| Canonical SMILES | CC(C1=C2C(=CC=C1)N=C3C(=N2)C=CC=C3C(=O)O)OC(=O)CO |
| InChI | InChI=1S/C17H14N2O5/c1-9(24-14(21)8-20)10-4-2-6-12-15(10)18-13-7-3-5-11(17(22)23)16(13)19-12/h2-7,9,20H,8H2,1H3,(H,22,23) |
| InChI Key | LHVPYDKBRGMWJO-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Acicular Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor) |
| Boiling Point | 596.7°C at 760 mmHg |
| Melting Point | 185-187°C |
| Density | 1.455 g/cm3 |
Reference Reading
1. DC-86-M, a novel antitumor antibiotic. II. Structure determination and biological activities
K Takahashi, I Takahashi, M Morimoto, F Tomita J Antibiot (Tokyo). 1986 May;39(5):624-8. doi: 10.7164/antibiotics.39.624.
A novel antibiotic, DC-86-M was isolated from the culture broth of Streptomyces luteogriseus DO-86. The antibiotic has the molecular formula of C17H14N2O5 and belongs to the phenazine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine sarcoma 180.
2. DC-86-M, a novel antitumor antibiotic. I. Taxonomy of producing organism and fermentation
K Asano, K Takahashi, F Tomita, I Kawamoto J Antibiot (Tokyo). 1986 May;39(5):619-23. doi: 10.7164/antibiotics.39.619.
A novel antibiotic, DC-86-M was isolated from the culture broth of a new isolate, DO-86, from the soil sample collected in Machida-shi, Japan. The producing organism was found to belong to Streptomycetes, for it formed aerial mycelia and chains of spores and its cell wall analyses revealed the presence of LL-diaminopimelic acid. The morphological, cultural and physiological characteristics of the strain DO-86 resemble closely those of Streptomyces luteogriseus and we concluded that the strain DO-86 could be designated as Streptomyces luteogriseus DO-86. The antibiotic was produced in the fermentation medium consisting of lactose 20 g, glucose 10 g, Pharmamedia 15 g, yeast extract 5 g, meat extract 10 g and CaCO3 2 g per liter of tap water.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
