Deflectin 1a
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-00795 |
| CAS | 79495-61-7 |
| Molecular Weight | 356.41 |
| Molecular Formula | C21H24O5 |
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Description
Deflectin 1a is an antibiotic produced by Aspergillus deflectus. It has the activity of lysing bacteria, lysing red blood cells and inhibiting Ehrlich ascites cancer cells, and its activity can be offset by adding serum or serum albumin.
Specification
| IUPAC Name | (6aR)-3,6a-dimethyl-9-octanoylfuro[2,3-h]isochromene-6,8-dione |
| Canonical SMILES | CCCCCCCC(=O)C1=C2C3=COC(=CC3=CC(=O)C2(OC1=O)C)C |
| InChI | InChI=1S/C21H24O5/c1-4-5-6-7-8-9-16(22)18-19-15-12-25-13(2)10-14(15)11-17(23)21(19,3)26-20(18)24/h10-12H,4-9H2,1-3H3/t21-/m0/s1 |
| InChI Key | YNVKQPJBOAUYIJ-NRFANRHFSA-N |
Properties
| Melting Point | 161°C |
Reference Reading
1. When citizen science is public relations
Sarah Blacker, Aya H Kimura, Abby Kinchy Soc Stud Sci. 2021 Oct;51(5):780-796. doi: 10.1177/03063127211027662. Epub 2021 Jul 2.
Amid rising interest in participatory research, some industries have recently begun to practice public relations citizen science (PRCS). Unlike citizen science and crowdsourcing projects that generate raw materials for product development, PRCS benefits capitalist firms primarily by improving their public image and deflecting accusations of causing harm. Three cases illustrate how PRCS works: (1) a growing assortment of citizen science projects associated with Antarctic tourism, (2) an initiative to document biodiversity, linked to Canada's oil and gas industry, and (3) a study sponsored by Biology Fortified, a nonprofit organization that works to communicate positive information about agricultural biotechnology. Scientists and research organizations may have legitimate reasons for entering into these partnerships, but PRCS can benefit industries in problematic ways. First, by supporting environmental science, PRCS can attach a 'sustainable' image to a polluting industry, without changing its core practices. Second, PRCS can accumulate data and steer volunteers' observations in ways that undermine claims about the harms caused by the industry's practices or products. Finally, in some cases, PRCS organizers hope to induce people to view an industry more 'rationally' than those who make 'emotional' or 'ideological' claims about its harms.
2. The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping
Alan A Hopkins, Rory Murphy, Mustapha Irnaten, Deborah M Wallace, Barry Quill, Colm O'Brien Am J Physiol Cell Physiol. 2020 Oct 1;319(4):C611-C623. doi: 10.1152/ajpcell.00054.2020. Epub 2020 Jul 15.
The primary biomechanical driver of pathological glaucomatous cupping remains unknown. Finite element modeling indicates that stress and strain play key roles. In this article, primarily a review, we utilize known biomechanical data and currently unpublished results from our lab to propose a three-stage, tissue stiffness-based model to explain glaucomatous cupping occurring at variable levels of translaminar pressure (TLP). In stage 1, a short-term increase in TLP gradient induces a transient increase in lamina cribrosa (LC) strain. Beyond a critical level of strain, the tissue stiffness rises steeply provoking cellular responses via integrin-mediated mechanotransduction. This early mechanoprotective cellular contraction reduces strain, which reduces tissue stiffness by return of the posteriorly deflected LC to baseline. In stage 2 a prolonged period of TLP increase elicits extracellular matrix (ECM) production leading to fibrosis, increasing baseline tissue stiffness and strain and diminishing the contractile ability/ability to return to the baseline LC position. This is supported by our three-dimensional collagen contraction assays, which show significantly reduced capacity to contract in glaucoma compared with normal LC cells. Second, 15% cyclic strain in LC cells over 24 h elicits a typical increase in ECM profibrotic genes in normal LC cells but a highly blunted response in glaucoma LC cells. Stage 3 is characterized by persistent fibrosis causing further stiffening and inducing a feed-forward ECM production cycle. Repeated cycles of increased strain and stiffness with profibrotic ECM deposition prevent optic nerve head (ONH) recoil from the new deflected position. This incremental maladaptive modeling leads to pathological ONH cupping.
3. Numerical Investigation of Overtopping Prevention for Optimal Safety Dike Design
Namjeong Son, Yoojin Kim, Mimi Min, Seungho Jung, Chankyu Kang Int J Environ Res Public Health. 2022 Dec 7;19(24):16429. doi: 10.3390/ijerph192416429.
Leakage accidents at chemical facilities have a negative impact on both the environment and human life, and the government has established and implemented regulations on dikes in order to minimize such accidents. However, the overtopping phenomenon in which chemicals overflow the dike due to catastrophic leakage requires additional safeguards. In this study, the mitigation effect was confirmed by simulating tanks and dikes using various deflector plates to minimize the effect of spilled chemicals. ANSYS Fluent 19.1, a computational fluid dynamics program, was used, and the overtopping effect was compared with a dike design that satisfies the safety regulations using a volume of fluid (VOF) model that analyzes multiphase flow through a surface tracking technique. Nitric acid and sulfuric acid were used in the study; they were selected because they are frequently involved in leakage accidents. In the event of a leak in a liquid tank, a dike with a deflector plate was very effective in reducing overtopping, and a deflector at a 45° angle was more effective than a 30° deflector. However, it is necessary to install additional safeguards at the joint between the dike and the deflection plate to withstand the force of the liquid.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
