Demethylbleomycin A2 sulfate

Demethylbleomycin A2 sulfate

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Category Antibiotics
Catalog number BBF-04319
CAS
Molecular Weight 1400.51 (free base)
Molecular Formula C54H81N17O21S3.xH2SO4
Purity ≥90%

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Description

A demethylated form of bleomycin A2 which is a major component in standard grade bleomycin. It is formed by heating bleomycin A2. It has high antimicrobial activity against mycobacterium smegmatis compared to bleomycin A2. It has a lower toxicity.

Specification

Related CAS 41089-03-6 (free base)
Synonyms Bleomycin DM-A2 sulfate; N1-[3-(Methylthio)propyl]bleomycinamide sulfate
Storage Store at -20°C under inert atmosphere
IUPAC Name [(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-(3-methylsulfanylpropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate;sulfate

Properties

Appearance Off-white Solid
Antibiotic Activity Spectrum Mycobacteria
Solubility Slightly soluble in Acetonitrile, Water

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