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Dioxolamycin

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Dioxolamycin
Category Antibiotics
Catalog number BBF-01161
CAS 91432-46-1
Molecular Weight 257.24
Molecular Formula C11H15NO6

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Streptomyces filamentosus MC521-C5. It can inhibit L-1210 cell activity.

  • Specification
  • Properties
  • Reference Reading
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Synonyms 1,3-Benzodioxole-5-carboxylic acid, 2-(aminocarbonyl)-3a,6,7,7a-tetrahydro-7-hydroxy-2-methyl-, methyl ester, (2S,3aR,7R,7aR)-
IUPAC Name methyl (2S,3aR,7R,7aR)-2-carbamoyl-7-hydroxy-2-methyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-5-carboxylate
Canonical SMILES CC1(OC2C=C(CC(C2O1)O)C(=O)OC)C(=O)N
InChI InChI=1S/C11H15NO6/c1-11(10(12)15)17-7-4-5(9(14)16-2)3-6(13)8(7)18-11/h4,6-8,13H,3H2,1-2H3,(H2,12,15)/t6-,7-,8-,11+/m1/s1
InChI Key SHAXHGRARCZUPJ-NKIIXMILSA-N
Appearance Colorless Crystal
Antibiotic Activity Spectrum Neoplastics (Tumor)
Boiling Point 498.8±45.0 °C at 760 mmHg
Melting Point 214-215 °C
Density 1.386±0.06 g/cm3 (20 °C, 760 mmHg)
Solubility Soluble in Methanol; Insoluble in Water
1. [Studies on the synthesis and bioactivity of some new shikimic acid derivatives]
K L Sun, R S Li, X H Lei Yao Xue Xue Bao. 1990;25(1):73-6.
Ten new shikimic acid derivatives, some of which are analogs of dioxolamycin were synthesized from methyl shikimate because the bioactivity of shikimic acid derivatives has received considerably less attention to date. Compounds 4-10, 12, 16 were subjected to antimicrobial test in vitro, and showed no activity (MIC greater than 25 micrograms/ml). Compounds 4-10, 12, 13, and 16 were subjected to cytostatic activity test against cultured L 1210 Leukemia cells in vitro. Compounds 4, 6, 13 and 16 showed cytostatic activity like dioxolamycin.
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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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