Dioxolamycin
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| Category | Antibiotics |
| Catalog number | BBF-01161 |
| CAS | 91432-46-1 |
| Molecular Weight | 257.24 |
| Molecular Formula | C11H15NO6 |
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Description
It is produced by the strain of Streptomyces filamentosus MC521-C5. It can inhibit L-1210 cell activity.
Specification
| Synonyms | 1,3-Benzodioxole-5-carboxylic acid, 2-(aminocarbonyl)-3a,6,7,7a-tetrahydro-7-hydroxy-2-methyl-, methyl ester, (2S,3aR,7R,7aR)- |
| IUPAC Name | methyl (2S,3aR,7R,7aR)-2-carbamoyl-7-hydroxy-2-methyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-5-carboxylate |
| Canonical SMILES | CC1(OC2C=C(CC(C2O1)O)C(=O)OC)C(=O)N |
| InChI | InChI=1S/C11H15NO6/c1-11(10(12)15)17-7-4-5(9(14)16-2)3-6(13)8(7)18-11/h4,6-8,13H,3H2,1-2H3,(H2,12,15)/t6-,7-,8-,11+/m1/s1 |
| InChI Key | SHAXHGRARCZUPJ-NKIIXMILSA-N |
Properties
| Appearance | Colorless Crystal |
| Antibiotic Activity Spectrum | Neoplastics (Tumor) |
| Boiling Point | 498.8±45.0 °C at 760 mmHg |
| Melting Point | 214-215 °C |
| Density | 1.386±0.06 g/cm3 (20 °C, 760 mmHg) |
| Solubility | Soluble in Methanol; Insoluble in Water |
Reference Reading
1. [Studies on the synthesis and bioactivity of some new shikimic acid derivatives]
K L Sun, R S Li, X H Lei Yao Xue Xue Bao. 1990;25(1):73-6.
Ten new shikimic acid derivatives, some of which are analogs of dioxolamycin were synthesized from methyl shikimate because the bioactivity of shikimic acid derivatives has received considerably less attention to date. Compounds 4-10, 12, 16 were subjected to antimicrobial test in vitro, and showed no activity (MIC greater than 25 micrograms/ml). Compounds 4-10, 12, 13, and 16 were subjected to cytostatic activity test against cultured L 1210 Leukemia cells in vitro. Compounds 4, 6, 13 and 16 showed cytostatic activity like dioxolamycin.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
