Doramectin

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Doramectin
Category Antibiotics
Catalog number BBF-03802
CAS 117704-25-3
Molecular Weight 899.11
Molecular Formula C50H74O14
Purity 95%

Ordering Information

Catalog Number Size Price Stock Quantity
BBF-03802 25 g $299 In stock

Online Inquiry

Add to cart

Description

Doramectin is a derivative of ivermectin, which is an anthelmintic. Doramectin is an antiparasitic antibiotic produced by Streptomyces.

Specification

Synonyms UK67994
Storage Store at -20°C
IUPAC Name (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-cyclohexyl-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
Canonical SMILES CC1C=CC=C2COC3C2(C(C=C(C3O)C)C(=O)OC4CC(CC=C(C1OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)O)OC)OC)C)OC7(C4)C=CC(C(O7)C8CCCCC8)C)O
InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1
InChI Key QLFZZSKTJWDQOS-YDBLARSUSA-N
Source Streptomyces sp.

Properties

Appearance White to Off-white Solid
Antibiotic Activity Spectrum parasites
Boiling Point 967.4±65.0°C(Predicted)
Melting Point 160-163°C
Density 1.25±0.1 g/cm3(Predicted)
Solubility Soluble in ethanol, methanol, DMF, DMSO

Reference Reading

1. Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology
Kira J. Weissman. Nat. Prod. Rep.,2016, 33,203–230
By disabling the primary metabolic pathways leading to the native starter units, the inherent promiscuity of the Ave loading module was also used to generate a number of avermectin derivatives in S. avermitilis. The most effective antiparastic among them, doramectin (Dectomax), incorporates a cyclohexane carboxylic acid (CHC) as starter unit. It is, in fact, a showcase for polyketide pathway engineering, as it is the first drug to be derived from this approach, and is now one of the most successful veterinary anthelmintics. Recently, an attempt was made to engineer an alternative doramectin producer (Fig. 14) by exchanging the Ave loading module with that from the phoslactomycin PKS133 whose native substrate is CHC-CoA, coupled with introduction of a CHC-CoA biosynthetic pathway. The resulting strain did yield doramectin in amounts higher than that derived from supplementing the wild type strain with CHC (53 vs. 9mg L-1), but which were overall significantly reduced relative to avermectin production from the parent (500 mg L-1) – and native avermectin was also produced. Thus this system will require further improvements in order to be suitable for industrial-scale production of doramectin.

Recommended Products

BBF-00745 Cefteram pivoxil Inquiry
BBF-03211 AT-265 Inquiry
BBF-01851 Fumagillin Inquiry
BBF-05808 Triptolide Inquiry
BBF-02800 DB-2073 Inquiry
BBF-03756 Amygdalin Inquiry

Bio Calculators

Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

Recently viewed products

Online Inquiry

Verification code

Copyright © 2024 BOC Sciences. All rights reserved.

cartIcon
0
Inquiry Basket

No data available, please add!

Delete selectedGo to checkout

We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy

Accept Cookies
x