Dotriacolide
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01172 |
| CAS | 80994-06-5 |
| Molecular Weight | 973.28 |
| Molecular Formula | C40H76O18S4 |
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Description
It is produced by the strain of Micromonosporaechinospora MG199-fF35. It has inhibitory effects on β-lactamase, DNA enzyme and Topoisomerase I.
Specification
| Synonyms | Oxacyclodotriacont-3-en-2-one,16,18,30-tris(sulfooxy)-32-(8-(sulfooxy)nonyl)-; (Z)-32-oxo-2-(8-(sulfooxy)nonyl)oxacyclodotriacont-30-ene-4,16,18-triyl tris(hydrogen sulfate) |
| IUPAC Name | [2-oxo-18,30-disulfooxy-32-(8-sulfooxynonyl)-1-oxacyclodotriacont-3-en-16-yl] hydrogen sulfate |
| Canonical SMILES | CC(CCCCCCCC1CC(CCCCCCCCCCCC(CC(CCCCCCCCCCCC=CC(=O)O1)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O |
| InChI | InChI=1S/C40H76O18S4/c1-35(55-59(42,43)44)27-21-15-14-19-22-28-36-33-37(56-60(45,46)47)29-23-16-11-7-5-8-12-18-25-31-39(58-62(51,52)53)34-38(57-61(48,49)50)30-24-17-10-6-3-2-4-9-13-20-26-32-40(41)54-36/h26,32,35-39H,2-25,27-31,33-34H2,1H3,(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53) |
| InChI Key | YIIKXRWDWWBASM-UHFFFAOYSA-N |
Properties
| Appearance | Powder |
| Melting Point | 118 °C (dec.) |
| Density | 1.30 g/cm3 |
| Solubility | Soluble in Water, Methanol |
Reference Reading
1. Enhancement of mycinamicin production by dotriacolide in Micromonospora griseorubida
S Takenaka, K Yoshida, O Yamaguchi, K Shimizu, T Morohoshi, K Kinoshita FEMS Microbiol Lett. 1998 Oct 1;167(1):95-100. doi: 10.1111/j.1574-6968.1998.tb13213.x.
Production of macrolide antibiotic mycinamicin was greatly increased by addition of sulfate ion into the culture medium of Micromonospora griseorubida. An O-sulfate ester compound, also produced by the strain, was shown to be dotriacolide. In an M. griseorubida dotriacolide non-producing strain, the production level of mycinamicin remained low, but increased to the level of dotriacolide producing strain by the addition of dotriacolide. Dotriacolide enhanced mycinamicin production in M. griseorubida by the formation of micelles with mycinamicin. As a result, dotriacolide played a critical role in mycinamicin production in M. griseorubida.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
