Doxorubicin EP Impurity A (Daunorubicin)
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Category | Antibiotics |
Catalog number | BBF-01693 |
CAS | 20830-81-3 |
Molecular Weight | 527.52 |
Molecular Formula | C27H29NO10 |
Purity | 95% |
Catalog Number | Size | Price | Stock | Quantity |
---|---|---|---|---|
BBF-01693 | 500 mg | $399 | In stock | |
BBF-01693 | 1 g | $599 | In stock |
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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
Daunomycin is an anthracycline antibiotic produced by Streptomyces peucetius. The mechanism of action is the same as that of doxorubicin, which is inserted into DNA and inhibits RNA and DNA synthesis. It is mainly used for the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. It has anti-gram-positive bacteria, negative bacteria and tumor activity.
- Specification
- Properties
- Toxicity
- Reference Reading
- Spectrum
- Price Product List
Related CAS | 23541-50-6 (hydrochloride) |
Synonyms | (8S,10S)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Daunomycin; Acetyladriamycin; Leukaemomycin C; Cerubidine; Rubidomycin; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; RP-13057; NSC 82151; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; Epirubicin EP Impurity D |
Shelf Life | ≥360 days if stored properly |
Storage | Store at -20°C |
IUPAC Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
Canonical SMILES | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O |
InChI | InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1 |
InChI Key | STQGQHZAVUOBTE-VGBVRHCVSA-N |
Appearance | Orange-Red Powder |
Application | ADCs Cytotoxin |
Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor) |
Boiling Point | 769.977°C at 760 mmHg |
Melting Point | 208-209°C |
Flash Point | 419.5±32.9 °C |
Density | 1.554 g/cm3 |
Solubility | Soluble in Methanol, Water |
LogP | 1.83 |
Carcinogenicity | 2B, possibly carcinogenic to humans. |
Mechanism Of Toxicity | Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes. |
Toxicity | LD50 = 20 mg/kg (mice, IV); LD50 = 13 mg/kg (rat, IV). |
Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive

Experimental Conditions
Ionization Energy: 70 eV
Chromatography Type: Gas Chromatography Column (GC)
Instrument Type: Single quadrupole, spectrum predicted by CFM-ID(EI)
Mass Resolution: 0.0001 Da
Molecular Formula: C27H29NO10
Molecular Weight (Monoisotopic Mass): 527.1791 Da
Molecular Weight (Avergae Mass): 527.5199 Da
LC-MS/MS Spectrum - 40V, Positive

Predicted LC-MS/MS Spectrum - 10V, Positive

Experimental Conditions
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
Molecular Formula: C27H29NO10
Molecular Weight (Monoisotopic Mass): 527.1791 Da
Molecular Weight (Avergae Mass): 527.5199 Da
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
