EI-1507-1
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02808 |
| CAS | |
| Molecular Weight | 354.35 |
| Molecular Formula | C20H18O6 |
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Description
EI-1507-1 is produced by the strain of Streptomyces sp. E-1507. It had weak antibacterial activity, and it inhibited ICE with an IC50 of 0.23 μmol/L.
Specification
| IUPAC Name | 5,11-dihydroxy-13-methoxy-5-methyl-19-oxapentacyclo[8.8.1.01,10.02,7.012,17]nonadeca-2(7),8,12(17),13,15-pentaene-3,18-dione |
| Canonical SMILES | CC1(CC2=C(C(=O)C1)C34C(=O)C5=C(C(C3(O4)C=C2)O)C(=CC=C5)OC)O |
| InChI | InChI=1S/C20H18O6/c1-18(24)8-10-6-7-19-17(23)14-11(4-3-5-13(14)25-2)16(22)20(19,26-19)15(10)12(21)9-18/h3-7,17,23-24H,8-9H2,1-2H3 |
| InChI Key | DIZULAASFWJIGT-UHFFFAOYSA-N |
Properties
| Appearance | Light Brown Powder |
| Boiling Point | 657.1±55.0°C at 760 mmHg |
| Melting Point | 177-178°C |
| Density | 1.5±0.1 g/cm3 |
Reference Reading
1. EI-1507-1 and -2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1507
E Tsukuda, T Tanaka, K Ochiai, H Kondo, M Yoshida, T Agatsuma, Y Saitoh, S Teshiba, Y Matsuda J Antibiot (Tokyo). 1996 Apr;49(4):333-9. doi: 10.7164/antibiotics.49.333.
EI-1507-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1507. EI-1507-1 and EI-1507-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.23 and 0.42 microM, respectively. EI-1507-1 and EI-1507-2 also inhibited mature interleukin-1 beta secretion from THP-1 cells with IC50 values of 1.1 and 1.4 microM, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
