EI-2346
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02816 |
| CAS | |
| Molecular Weight | 434.44 |
| Molecular Formula | C22H26O9 |
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Description
EI-2346 is originally isolated from Streptomyces sp. E-2346. It selectively inhibited ICE, and the IC50 of recombinant human ICE was 3.9 μmol/L. It also inhibits elastase and cathepsin.
Specification
| Synonyms | 3,10-Dihydroxy-8-[5-hydroxy-4-(hydroxymethyl)-1,3-dioxan-2-yl]-3-methyl-1-propyl-3,4-dihydro-1H-benzo[g]isochromene-6,9-dione |
| IUPAC Name | 3,10-dihydroxy-8-[5-hydroxy-4-(hydroxymethyl)-1,3-dioxan-2-yl]-3-methyl-1-propyl-1,4-dihydrobenzo[g]isochromene-6,9-dione |
| Canonical SMILES | CCCC1C2=C(C3=C(C=C2CC(O1)(C)O)C(=O)C=C(C3=O)C4OCC(C(O4)CO)O)O |
| InChI | InChI=1S/C22H26O9/c1-3-4-15-17-10(7-22(2,28)31-15)5-11-13(24)6-12(19(26)18(11)20(17)27)21-29-9-14(25)16(8-23)30-21/h5-6,14-16,21,23,25,27-28H,3-4,7-9H2,1-2H3 |
| InChI Key | AIECNKXPJPEPNW-UHFFFAOYSA-N |
Properties
| Appearance | Orange Oily Matter |
| Boiling Point | 689.3±55.0°C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties
Fumito Koizumi, Atsuhiro Hasegawa, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Mayumi Yoshida, Yuzuru Matsuda, Satoshi Nakanishi J Antibiot (Tokyo). 2003 Dec;56(12):985-92. doi: 10.7164/antibiotics.56.985.
EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC50 value of 3.9 microM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with an IC50 value of 5.2 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
