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Ethambutol dihydrochloride

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Ethambutol dihydrochloride
Category Others
Catalog number BBF-03793
CAS 1070-11-7
Molecular Weight 277.23
Molecular Formula C10H24N2O2.2HCl
Purity >98%

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4 R&D and scale-up labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Ethambutol dihydrochloride is a hydrochloride salt of Ethambutol. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

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Related CAS 74-55-5 (free base)
Synonyms CL40881; CL 40881; CL-40881; Myambutol; Dadibutol
Storage Store at 2-8°C
IUPAC Name (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;dihydrochloride
Canonical SMILES CCC(CO)NCCNC(CC)CO.Cl.Cl
InChI InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0./s1
InChI Key AUAHHJJRFHRVPV-BZDVOYDHSA-N
Appearance White to Off-white Solid
Application Antitubercular Agents
Antibiotic Activity Spectrum mycobacteria
Boiling Point 345.3°C at 760 mmHg
Melting Point 197-200°C
1.Drug resistant strains of Mycobacterium tuberculosis identified through PCR-RFLP from patients of Central Punjab, Pakistan.
Riaz M1, Mahmood Z2, Javed MT3, Javed I1, Shahid M1, Abbas M4, Ehtisham-Ul-Haque S5. Int J Immunopathol Pharmacol. 2016 Apr 11. pii: 0394632016638100. [Epub ahead of print]
The study was carried out to determine, by PCR-RFLP, the magnitude of drug resistance inMycobacterium tuberculosis The study was carried out on 221 random sputum samples collected from patients and 120 suspected cases of drug resistance. Genetic variation in drug-resistant strains was evaluated through PCR-RFLP for isoniazid, ethambutol, streptomycin, and ofloxacin. Out of 341 patients, 91.5% were confirmed asM. tuberculosiscomplex infected on the basis of PCR. The random samples revealed resistance in 8.2% cases, while 73.3% of those with suspected drug resistance were found resistant. Among drug-resistant isolates, 56.1% were resistant to a single drug, 33.3% to two drugs, and 10.6% to more than two drugs. Ofloxacin resistance was observed along with isoniazid, ethambutol, and streptomycin in 6.5% cases. Resistance to isoniazid was observed in 61% cases, to ethambutol in 50.4%, and to streptomycin in 43.1% cases. It was concluded that PCR-RFLP is a useful molecular technique for the rapid detection of mutations in drug-resistant tuberculosis patients and may be used to diagnose drug resistance at the earliest.
2.External Quality Assessment for Tuberculosis Diagnosis and Drug Resistance in the European Union: A Five Year Multicentre Implementation Study.
Nikolayevskyy V1,2, Hillemann D3, Richter E3, Ahmed N1, van der Werf MJ4, Kodmon C4, Drobniewski F1,2, Ruesch-Gerdes S3; ERLTB-Net Network. PLoS One. 2016 Apr 7;11(4):e0152926. doi: 10.1371/journal.pone.0152926. eCollection 2016.
BACKGROUND: External quality assurance (EQA) systems are essential to ensure accurate diagnosis of TB and drug-resistant TB. The implementation of EQA through organising regular EQA rounds and identification of training needs is one of the key activities of the European TB reference laboratory network (ERLTB-Net). The aim of this study was to analyse the results of the EQA rounds in a systematic manner and to identify potential benefits as well as common problems encountered by the participants.
3.Update meta-analysis of the CYP2E1 RsaI/PstI and DraI polymorphisms and risk of antituberculosis drug-induced hepatotoxicity: evidence from 26 studies.
Wang FJ1, Wang Y2, Niu T1, Lu WX3, Sandford AJ4, He JQ2. J Clin Pharm Ther. 2016 Apr 9. doi: 10.1111/jcpt.12388. [Epub ahead of print]
WHAT IS KNOWN AND OBJECTIVE: Several studies have investigated the association of the CYP2E1 RsaI/PstI and/or DraI polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity (ATDH), but the results have been inconsistent. Therefore, we performed a large meta-analysis to determine a more precise estimation of this relationship.
4.Sensititre® MYCOTB MIC plate for drug susceptibility testing of Mycobacterium tuberculosis complex isolates.
Yu X1, Ma YF1, Jiang GL1, Chen ST1, Wang GR1, Huang HR2. Int J Tuberc Lung Dis. 2016 Mar;20(3):329-34. doi: 10.5588/ijtld.15.0573.
SETTING: National Tuberculosis Clinical Laboratory, China.

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