Ethyl 4-O-methylhaematommate
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| Category | Others |
| Catalog number | BBF-05323 |
| CAS | 38629-37-7 |
| Molecular Weight | 238.24 |
| Molecular Formula | C12H14O5 |
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Description
Ethyl 4-O-methylhaematommate is a derivative of Haematomma, which is a genus of crustose lichens.
Specification
| Synonyms | Benzoic acid, 3-formyl-2-hydroxy-4-methoxy-6-methyl-, ethyl ester; ethyl 2-hydroxy-3-formyl-4-methoxy-6-methylbenzoate; 3-Formyl-2-hydroxy-4-methoxy-6-methylbenzoic acid ethyl ester |
| IUPAC Name | ethyl 3-formyl-2-hydroxy-4-methoxy-6-methylbenzoate |
| Canonical SMILES | CCOC(=O)C1=C(C(=C(C=C1C)OC)C=O)O |
| InChI | InChI=1S/C12H14O5/c1-4-17-12(15)10-7(2)5-9(16-3)8(6-13)11(10)14/h5-6,14H,4H2,1-3H3 |
| InChI Key | YQMIEZNZSAHWLU-UHFFFAOYSA-N |
Properties
| Boiling Point | 354.6±42.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. Copper-catalyzed N-methylation/ethylation of sulfoximines
Fan Teng, Jiang Cheng, Jin-Tao Yu Org Biomol Chem. 2015 Oct 21;13(39):9934-7. doi: 10.1039/c5ob01558h.
A protocol for the copper-catalyzed N-methylation of sulfoximines with di-tert-butyl peroxide (DTBP) was developed. This protocol has good functional group tolerance leading to N-methylated sulfoximines in moderate to good yields. Besides, N-ethylation of sulfoximines was achieved in the presence of bis(1,1-dimethylpropyl)peroxide as the ethylating agent under a standard procedure.
2. Lysine Ethylation by Histone Lysine Methyltransferases
Abbas H K Al Temimi, Michael Martin, Qingxi Meng, Danny C Lenstra, Ping Qian, Hong Guo, Elmar Weinhold, Jasmin Mecinović Chembiochem. 2020 Feb 3;21(3):392-400. doi: 10.1002/cbic.201900359. Epub 2019 Oct 24.
Biomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) cosubstrate to lysine residues in histones and other proteins. Herein, experimental and computational investigations on human KMT-catalyzed ethylation of histone peptides by using S-adenosylethionine (AdoEth) and Se-adenosylselenoethionine (AdoSeEth) cosubstrates are reported. MALDI-TOF MS experiments reveal that, unlike monomethyltransferases SETD7 and SETD8, methyltransferases G9a and G9a-like protein (GLP) do have the capacity to ethylate lysine residues in histone peptides, and that cosubstrates follow the efficiency trend AdoMet>AdoSeEth>AdoEth. G9a and GLP can also catalyze AdoSeEth-mediated ethylation of ornithine and produce histone peptides bearing lysine residues with different alkyl groups, such as H3K9meet and H3K9me2et. Molecular dynamics and free energy simulations based on quantum mechanics/molecular mechanics potential supported the experimental findings by providing an insight into the geometry and energetics of the enzymatic methyl/ethyl transfer process.
3. EMS Mutagenesis of Arabidopsis Seeds
C Stewart Gillmor, Wolfgang Lukowitz Methods Mol Biol. 2020;2122:15-23. doi: 10.1007/978-1-0716-0342-0_2.
The ethylating agent ethyl methanesulfonate (EMS) is widely used for inducing random point mutations. In Arabidopsis, treatment with EMS causes GC-to-AT transitions with great efficiency: it has been estimated that a population of 50,000 well-mutagenized plants harbors one or more transitions in almost every GC pair of the genome. These properties, combined with ease of use, make EMS a mutagen of choice for genetic screens. Here, we describe a protocol for mutagenizing Arabidopsis seed with EMS. In addition, we briefly consider the germ line sectors typically induced by this treatment, and approaches for estimating the rate of induced mutations.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
