F390B
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| Category | Antibiotics |
| Catalog number | BBF-02823 |
| CAS | |
| Molecular Weight | 344.31 |
| Molecular Formula | C18H16O7 |
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Description
It is an anti-tumor antibiotic produced by Penicillum sp.AJ 117292.
Specification
| Synonyms | F-390B; F-390-B; methyl (4R,4aS)-4-(acetyloxy)-8-hydroxy-6-methyl-9-oxo-4,9-dihydro-4aH-xanthene-4a-carboxylate |
| IUPAC Name | methyl (4R,4aS)-4-acetyloxy-8-hydroxy-6-methyl-9-oxo-4H-xanthene-4a-carboxylate |
| Canonical SMILES | CC1=CC(=C2C(=C1)OC3(C(C=CC=C3C2=O)OC(=O)C)C(=O)OC)O |
| InChI | InChI=1S/C18H16O7/c1-9-7-12(20)15-13(8-9)25-18(17(22)23-3)11(16(15)21)5-4-6-14(18)24-10(2)19/h4-8,14,20H,1-3H3/t14-,18+/m1/s1 |
| InChI Key | OOXFQLGEGVNXBG-KDOFPFPSSA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
Reference Reading
1. Inhibition of DNA topoisomerases by nidulalin A derivatives
S Sato, Y Fukuda, R Nakagawa, T Tsuji, K Umemura, T Andoh Biol Pharm Bull. 2000 Apr;23(4):511-2. doi: 10.1248/bpb.23.511.
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 microM.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
