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F390C

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F390C
Category Antibiotics
Catalog number BBF-02824
CAS
Molecular Weight 318.28
Molecular Formula C16H14O7

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is an anti-tumor antibiotic produced by Penicillum sp.AJ 117292.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms F-390C; F-390-C; methyl (4R,4aS)-4,8-dihydroxy-6-(hydroxymethyl)-9-oxo-4,9-dihydro-4aH-xanthene-4a-carboxylate
IUPAC Name methyl (4R,4aS)-4,8-dihydroxy-6-(hydroxymethyl)-9-oxo-4H-xanthene-4a-carboxylate
Canonical SMILES COC(=O)C12C(C=CC=C1C(=O)C3=C(C=C(C=C3O2)CO)O)O
InChI InChI=1S/C16H14O7/c1-22-15(21)16-9(3-2-4-12(16)19)14(20)13-10(18)5-8(7-17)6-11(13)23-16/h2-6,12,17-19H,7H2,1H3/t12-,16+/m1/s1
InChI Key PMHCAQUSIVAZPO-WBMJQRKESA-N
Appearance Yellow Powder
Antibiotic Activity Spectrum neoplastics (Tumor)
1. Inhibition of DNA topoisomerases by nidulalin A derivatives
S Sato, Y Fukuda, R Nakagawa, T Tsuji, K Umemura, T Andoh Biol Pharm Bull. 2000 Apr;23(4):511-2. doi: 10.1248/bpb.23.511.
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 microM.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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