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Ferrocin C

Name: Ferrocin C
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Others
Catalog number	BBF-02026
CAS	147736-85-4
Molecular Weight	1263.15
Molecular Formula	C53H84FeN13O19

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Ferrocin C is an iron chelating cyclic decapeptide produced by Pseudomonas fluorescens YK-310. It has anti-gram-negative bacterial activity.

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IUPAC Name	(Z)-N-[(12S,18S,21R,30S)-18-(hydroxymethyl)-12-methyl-6,15,27-tris[3-[oxido(propanoyl)amino]propyl]-2,5,8,11,17,20,23,26,29-nonaoxo-21-propan-2-yl-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]dec-3-enamide;iron(3+)
Canonical SMILES	CCCCCCC=CCC(=O)NC1COC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NCC(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC1=O)CCCN(C(=O)CC)[O-])C(C)C)CO)CCCN(C(=O)CC)[O-])C)CCCN(C(=O)CC)[O-].[Fe+3]
InChI	InChI=1S/C54H90N13O18.Fe/c1-8-12-13-14-15-16-17-24-41(69)61-40-33-85-47(75)31-58-50(77)37(22-19-26-66(83)45(73)10-3)60-42(70)29-56-49(76)35(7)55-28-36(21-18-25-65(82)44(72)9-2)59-52(79)39(32-68)63-54(81)48(34(5)6)64-43(71)30-57-51(78)38(62-53(40)80)23-20-27-67(84)46(74)11-4;/h16-17,34-40,48,55,68H,8-15,18-33H2,1-7H3,(H,56,76)(H,57,78)(H,58,77)(H,59,79)(H,60,70)(H,61,69)(H,62,80)(H,63,81)(H,64,71);/q-3;+3/b17-16-;/t35-,36?,37?,38?,39-,40-,48+;/m0./s1
InChI Key	RMTLRGLVFMRELD-ZHMJLKBJSA-N

Appearance	Orange Powder
Antibiotic Activity Spectrum	Gram-negative bacteria

1. Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Isolation, characterization and structure elucidation

S Tsubotani, N Katayama, Y Funabashi, H Ono, S Harada J Antibiot (Tokyo). 1993 Feb;46(2):287-93. doi: 10.7164/antibiotics.46.287.

Novel iron-containing peptide antibiotics, ferrocins A, B, C and D, have been isolated from the culture filtrate of Pseudomonas fluorescens YK-310. These antibiotics were purified by butanol extraction, followed by column chromatography using adsorption resin, silica gel and preparative reverse-phase HPLC. The structures of ferrocins were elucidated using spectroscopic and degradative methods. Ferrocins contain three hydroxamate moieties per ferric ion which forms an octahedral iron complex.

2. Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Taxonomy, fermentation and biological activity

N Katayama, Y Nozaki, K Okonogi, S Harada, H Ono J Antibiot (Tokyo). 1993 Jan;46(1):65-70. doi: 10.7164/antibiotics.46.65.

A Gram-negative bacterium was found to produce new iron-containing peptide antibiotics, ferrocins A, B, C and D, and the producing bacterium was characterized and identified as Pseudomonas fluorescens YK-310. These new antibiotics showed antibacterial activity against Gram-negative bacteria in vitro. Although the ferrocins showed similar antibacterial activity against both Escherichia coli and Pseudomonas aeruginosa on the standard assay media, they showed strong therapeutic effects selectively against P. aeruginosa in experimentally infected mice.

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