Flagranone B

Flagranone B

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-00933
CAS
Molecular Weight 362.33
Molecular Formula C18H18O8

Online Inquiry

Description

Flagranone B is a cyclohexenone oxide antibiotic produced by Duddingtonia flagrans. It has anti-Gram-positive bacteria activity, with MICs of 50 and 100 μg/mL for Bacillus subtilis and Staphylococcus aureus, respectively. It can also inhibit the growth of gram-negative bacteria at 100 μg/mL and has an inhibitory effect on several penicillium bacteria.

Specification

IUPAC Name [6-[(2E,4E)-1-acetyloxy-3-methyl-6-oxohexa-2,4-dienyl]-2,5-dioxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]methyl acetate
Canonical SMILES CC(=CC(C12C(O1)C(=O)C(=CC2=O)COC(=O)C)OC(=O)C)C=CC=O
InChI InChI=1S/C18H18O8/c1-10(5-4-6-19)7-15(25-12(3)21)18-14(22)8-13(9-24-11(2)20)16(23)17(18)26-18/h4-8,15,17H,9H2,1-3H3/b5-4+,10-7+
InChI Key SVNKMLNHRUIBIV-YIORLJKJSA-N

Properties

Appearance Yellow Oil
Antibiotic Activity Spectrum Gram-positive bacteria

Reference Reading

1. Molecular detection of Campylobacter spp. in drinking, recreational and environmental water supplies
J Moore, P Caldwell, B Millar Int J Hyg Environ Health. 2001 Nov;204(2-3):185-9. doi: 10.1078/1438-4639-00096.
A molecular detection assay was performed on 207 samples of drinking, recreational and environmental waters collected in Northern Ireland. The water sources which were PCR positive for Campylobacter spp. included 2/91 (2.2%) drinking water from domestic household taps, 5/57 (8.8%) swimming pool water, 1/23 (4.3%) lake water and 1/1 water from a jacuzzi. Extracted DNA from all water samples was amplified employing a sequence-specific PCR assay based on a 206 bp conserved region of the flagellin A-flagellin B (flaA/flaB) loci for Campylobacter jejuni, C. coli and C. lari. Given the physiological and cultural fragile nature of these species, no waters were cultured using conventional methods due to concern for reversion to non-culturability from time of collection to laboratory analysis. As this genus has been demonstrated to form a 'viable but non-culturable' (VBNC) form, failure to culture organisms conventionally from water does not necessarily equate to a negative result, hence molecular detection assays, especially those which can demonstrate cell viability, may be useful in helping to elucidate potential epidemiological sources and reservoirs of this organism, especially where water is suspected as being the vehicle of transmission.
2. Structures of flagranones A, B and C, cyclohexenoxide antibiotics from the nematode-trapping fungus Duddingtonia flagrans
M G Anderson, R W Rickards, E Lacey J Antibiot (Tokyo). 1999 Nov;52(11):1023-8. doi: 10.7164/antibiotics.52.1023.
Spectroscopic data define the structures of the flagranones A (2), B (3) and C (4) from the nematode-trapping fungus Duddingtonia flagrans. These antibiotics are structurally related to the farnesylated cyclohexenoxides of the oligosporon group recently isolated from the nematode-trapping fungus Arthrobotrys oligospora, and show similar antimicrobial activity.

Recommended Products

Bio Calculators

  • Solution Dilution Calculator
  • Molecular Weight Calculator
  • Molarity Calculator
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g

Recently viewed products

Pelagiomicin B | Flagranone B

Online Inquiry

Verification code

Our Products

Need Assistance?

  • US & Canada:
    +1-844-BOC(262)-0123
  • UK: +44-203-286-1088
CONTACT US

Capabilities & Facilities

Fermentation CDMO Service

Our Advantages

Application Area

USA

  • International : 
    US & Canada (Toll free):
  • Fax:
  • Email:

UK

  • Tel:
  • Email:

Products

Services

Copyright © 2024 BOC Sciences. All rights reserved.

cartIcon
Inquiry Basket
Loading ......
Delete selectedGo to checkout