Flumethasone

Flumethasone

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Flumethasone
Category Others
Catalog number BBF-03851
CAS 2135-17-3
Molecular Weight 410.45
Molecular Formula C22H28F2O5
Purity 99%

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Description

Flumethasone is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortiso assays to study early porcine conceptus development.

Specification

Synonyms RS 2177; RS-2177; RS2177; NSC 54702; U-10,974; U-10974; Anaprime; Aniprime; Fluvet; Methagon; BRN 5645455; Cortexilar; Flucort
Storage Store at 2-8°C
IUPAC Name (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Canonical SMILES CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F
InChI InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
InChI Key WXURHACBFYSXBI-GQKYHHCASA-N

Properties

Appearance White to Off-white Crystalline Powder
Application Anti-Inflammatory Agents
Boiling Point 569.8°C at 760 mmHg
Melting Point 237-240°C
Flash Point 298.4ºC
Density 1.36 g/cm3
LogP 1.84370

Reference Reading

1. Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry
Alejandra Iglesias & Carolina Nebot & Jose M. Miranda & Beatriz I. Vázquez & Alberto Cepeda. Environ Sci Pollut Res (2012) 19:3235–3249
The results of the samples analysed indicated that 23% of the samples tested were positive for the presence of one or more of the selected veterinary drugs, and 43% of them were collected in farming areas. These results could indicate that the presence of the veterinary drugs detected in the water samples collected from rural areas could come from the use of manure contaminated with veterinary drugs (Carballas 1991). Due to the fact that manure samples were not analysed in this study, this affirmation could only be ahypothesis. Eleven drugs were detected in the river samples; trimethoprim, sulfapyridine, sulfaquinoxaline, sulfadiazine, sulfamethoxypyridazine, sulfamethazine, decoquinate, monensin, salinomycin, maduramycin and flumethasone. Among all of the drugs detected in natural water samples, trimethoprim was the most frequently detected in 13 samples which was followed by sulfapyridine in 11 samples. The analytes detected and concentrations are summarized in Table 7.The rest of the pharmaceuticals selected were not detected in any of the river samples; they might be present in the samples but at a concentration below their LOD (Table 4). Figure 2 shows MRM chromatograms of positive samples for decoquinate, flumethasone, sulfadiazine and trimethoprim quantified at 40.0, 85.1, 2978.6 and 126.1 ng L−1 (Table 7), detected in Galician river water samples.

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