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Fluopsin B

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Fluopsin B
Category Antibiotics
Catalog number BBF-00942
CAS 31323-26-9
Molecular Weight 326.22
Molecular Formula C6H12FeN3O3S3

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Fluopsin B is an antibiotic containing metallic iron produced by Pseudomonas fluorescent KY 4032 cultured with n-alkane as a carbon source. It has strong anti-Gram-positive and negative bacteria activity and anti-tumor activity.

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Related CAS 36763-17-4
Synonyms Tris(N-hydroxy-N-methylmethanethioamidato-O,S)iron; Fluopsin F
IUPAC Name iron(3+);N-methyl-N-oxidomethanethioamide
Canonical SMILES CN(C=S)[O-].CN(C=S)[O-].CN(C=S)[O-].[Fe+3]
InChI InChI=1S/3C2H4NOS.Fe/c3*1-3(4)2-5;/h3*2H,1H3;/q3*-1;+3
InChI Key ACYJCOROICMUFX-UHFFFAOYSA-N
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor)
Boiling Point 147°C at 760 mmHg
1. Antibiotics from Pseudomonas reptilivora. II. Isolation, purification, and properties
A A Del Rio, J L Gorgé, J Olivares, F Mayor Antimicrob Agents Chemother. 1972 Sep;2(3):189-94. doi: 10.1128/AAC.2.3.189.
Under well-established culture conditions, Pseudomonas reptilivora produced several antibiotics that have been purified by solvent extraction, chromatography in Sephadex G-25, electrophoresis, and paper chromatography in different solvent systems. Activity has been monitored at the different steps of isolation and purification by measurement of the inhibition of the growth of Staphylococcus aureus by the cylinder-plate method, as well as by bioautography of chromatograms and electropherograms. Three antibiotics have been isolated and named A, B(1), and B(2). The B(1) and B(2) activities were studied in greater detail than A. The B(1) substance was crystallized, and its chemical properties were found to coincide with those of YC 73 or fluopsin C described by Egawa et al. and Itoh et al., respectively.
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