Fluopsin N
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-00944 |
| CAS | 31541-90-9 |
| Molecular Weight | 238.94 |
| Molecular Formula | C4H8O2N2S2Ni |
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Description
Fluopsin N is an antibiotic containing metallic nickel produced by Pseudomonas fluorescent KY 4032 cultured with n-alkane as a carbon source. It has strong anti-Gram-positive and negative bacteria activity and anti-tumor activity.
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; neoplastics (Tumor) |
| Melting Point | 200-202°C |
Reference Reading
1. Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa
Jon B Patteson, Andrew T Putz, Lizhi Tao, William C Simke, L Henry Bryant rd, R David Britt, Bo Li Science. 2021 Nov 19;374(6570):1005-1009. doi: 10.1126/science.abj6749. Epub 2021 Nov 18.
Metal-binding natural products contribute to metal acquisition and bacterial virulence, but their roles in metal stress response are underexplored. We show that a five-enzyme pathway in Pseudomonas aeruginosa synthesizes a small-molecule copper complex, fluopsin C, in response to elevated copper concentrations. Fluopsin C is a broad-spectrum antibiotic that contains a copper ion chelated by two minimal thiohydroxamates. Biosynthesis of the thiohydroxamate begins with cysteine and requires two lyases, two iron-dependent enzymes, and a methyltransferase. The iron-dependent enzymes remove the carboxyl group and the α carbon from cysteine through decarboxylation, N-hydroxylation, and methylene excision. Conservation of the pathway in P. aeruginosa and other bacteria suggests a common role for fluopsin C in the copper stress response, which involves fusing copper into an antibiotic against other microbes.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
